Disease ID | Disease name | Source of annotation with A2M | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
104300 | ALZHEIMER DISEASE | OMIM | link to OMIM | 13 | HFE, PSEN2, ACE, APBB2, APP, A2M, PAXIP1, NOS3, MPO, PLAU, BLMH, PSEN1, SORL1 |
614036 | ALPHA-2-MACROGLOBULIN DEFICIENCY | OMIM | link to OMIM | 1 | A2M |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Complement and coagulation cascades | hsa04610 | 6.58 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Lipoprotein metabolism | R-HSA-174824 | 8.23 |
Platelet degranulation | R-HSA-114608 | 6.68 |
Rho GTPase cycle | R-HSA-194840 | 6.04 |
Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 8.52 |
Response to elevated platelet cytosolic Ca2+ | R-HSA-76005 | 6.59 |
Degradation of the extracellular matrix | R-HSA-1474228 | 6.11 |
Extracellular matrix organization | R-HSA-1474244 | 4.91 |
Metabolism | R-HSA-1430728 | 2.34 |
Lipid digestion, mobilization, and transport | R-HSA-73923 | 7.2 |
HDL-mediated lipid transport | R-HSA-194223 | 9.08 |
Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 7.7 |
Hemostasis | R-HSA-109582 | 3.98 |
Signal Transduction | R-HSA-162582 | 1.78 |
GO term | GO ID | GO IC |
---|---|---|
endopeptidase inhibitor activity | GO:0004866 | 4.6 |
C-X-C chemokine binding | GO:0019958 | 7.79 |
calcium-dependent protein binding | GO:0048306 | 5.68 |
chemokine binding | GO:0019956 | 6.69 |
cytokine binding | GO:0019955 | 5.21 |
enzyme binding | GO:0019899 | 2.27 |
binding | GO:0005488 | 0.18 |
enzyme inhibitor activity | GO:0004857 | 3.78 |
molecular function regulator | GO:0098772 | 2.51 |
interleukin-8 binding | GO:0019959 | 8.64 |
growth factor binding | GO:0019838 | 4.89 |
protease binding | GO:0002020 | 5.08 |
tumor necrosis factor binding | GO:0043120 | 9.05 |
endopeptidase regulator activity | GO:0061135 | 4.57 |
interleukin-1 binding | GO:0019966 | 7.79 |
enzyme regulator activity | GO:0030234 | 2.85 |
peptidase regulator activity | GO:0061134 | 4.37 |
GTPase activator activity | GO:0005096 | 4.11 |
GTPase regulator activity | GO:0030695 | 4.01 |
peptidase inhibitor activity | GO:0030414 | 4.55 |
serine-type endopeptidase inhibitor activity | GO:0004867 | 5.16 |
nucleoside-triphosphatase regulator activity | GO:0060589 | 3.92 |
protein binding | GO:0005515 | 0.46 |
receptor binding | GO:0005102 | 2.43 |
enzyme activator activity | GO:0008047 | 3.56 |