Gene table of A2M : alpha-2-macroglobulin

Gene-disease associations table

Disease IDDisease nameSource of annotation with A2MOMIM linkNumber of associated genesgenes
104300ALZHEIMER DISEASEOMIM link to OMIM 13HFE, PSEN2, ACE, APBB2, APP, A2M, PAXIP1, NOS3, MPO, PLAU, BLMH, PSEN1, SORL1
614036ALPHA-2-MACROGLOBULIN DEFICIENCYOMIM link to OMIM 1A2M

Download the gene annotation in CSV format

Annotation of the gene A2M

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Complement and coagulation cascadeshsa046106.58
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Lipoprotein metabolismR-HSA-1748248.23
Platelet degranulation R-HSA-1146086.68
Rho GTPase cycleR-HSA-1948406.04
Platelet activation, signaling and aggregationR-HSA-760025.15
Intrinsic Pathway of Fibrin Clot FormationR-HSA-1408378.52
Response to elevated platelet cytosolic Ca2+R-HSA-760056.59
Degradation of the extracellular matrixR-HSA-14742286.11
Extracellular matrix organizationR-HSA-14742444.91
MetabolismR-HSA-14307282.34
Lipid digestion, mobilization, and transportR-HSA-739237.2
HDL-mediated lipid transportR-HSA-1942239.08
Metabolism of lipids and lipoproteinsR-HSA-5568333.79
Signaling by Rho GTPasesR-HSA-1943154.43
Formation of Fibrin Clot (Clotting Cascade)R-HSA-1408777.7
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
endopeptidase inhibitor activityGO:00048664.6
C-X-C chemokine bindingGO:00199587.79
calcium-dependent protein bindingGO:00483065.68
chemokine bindingGO:00199566.69
cytokine bindingGO:00199555.21
enzyme bindingGO:00198992.27
bindingGO:00054880.18
enzyme inhibitor activityGO:00048573.78
molecular function regulatorGO:00987722.51
interleukin-8 bindingGO:00199598.64
growth factor bindingGO:00198384.89
protease bindingGO:00020205.08
tumor necrosis factor bindingGO:00431209.05
endopeptidase regulator activityGO:00611354.57
interleukin-1 bindingGO:00199667.79
enzyme regulator activityGO:00302342.85
peptidase regulator activityGO:00611344.37
GTPase activator activityGO:00050964.11
GTPase regulator activityGO:00306954.01
peptidase inhibitor activityGO:00304144.55
serine-type endopeptidase inhibitor activityGO:00048675.16
nucleoside-triphosphatase regulator activityGO:00605893.92
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
enzyme activator activityGO:00080473.56