Gene table of ACE : angiotensin I converting enzyme

Gene-disease associations table

Disease IDDisease nameSource of annotation with ACEOMIM linkNumber of associated genesgenes
614519HEMORRHAGE, INTRACEREBRAL, SUSCEPTIBILITY TOOMIM link to OMIM 3ACE, COL4A2, COL4A1
104300ALZHEIMER DISEASEOMIM link to OMIM 13HFE, PSEN2, ACE, APBB2, APP, A2M, PAXIP1, NOS3, MPO, PLAU, BLMH, PSEN1, SORL1
608446MYOCARDIAL INFARCTION, SUSCEPTIBILITY TOOMIM link to OMIM 14LTA, ACE, ITGB3, OLR1, GCLC, ESR1, GCLM, LGALS2, MIAT, LRP8, F7, PSMA6, F13A1, TNFSF4
267430RENAL TUBULAR DYSGENESISClinVar, OMIM link to OMIM 4REN, AGT, ACE, AGTR1
PS603933MICROVASCULAR COMPLICATIONS OF DIABETESOMIM link to OMIM 7EPO, ACE, PON1, IL1RN, SOD2, HFE, VEGFA

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Annotation of the gene ACE

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Chagas disease (American trypanosomiasis)hsa051425.99
Renin-angiotensin systemhsa046148.68
Hypertrophic cardiomyopathy (HCM)hsa054106.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Metabolism of Angiotensinogen to AngiotensinsR-HSA-20223778.98
Metabolism of proteinsR-HSA-3924993.41
Peptide hormone metabolismR-HSA-29807366.61
Associated GO terms for Molecular function
GO termGO IDGO IC
endopeptidase activityGO:00041753.63
enzyme bindingGO:00198992.27
drug bindingGO:00081445.03
exopeptidase activityGO:00082385.07
GO:00317118.64
bindingGO:00054880.18
G-protein coupled receptor bindingGO:00016644.18
peptidase activityGO:00082333.23
metalloexopeptidase activityGO:00082355.77
metallopeptidase activityGO:00082374.5
serine-type peptidase activityGO:00082364.27
anion bindingGO:00431684.17
cation bindingGO:00431691.4
transition metal ion bindingGO:00469142.48
mitogen-activated protein kinase kinase bindingGO:00314346.97
carboxypeptidase activityGO:00041806.0
dipeptidase activityGO:00168056.97
ion bindingGO:00431671.36
actin bindingGO:00037793.74
GO:00705738.64
metal ion bindingGO:00468721.41
hydrolase activityGO:00167871.9
mitogen-activated protein kinase bindingGO:00510196.56
serine hydrolase activityGO:00171714.26
tripeptidyl-peptidase activityGO:00082408.64
GO:00082418.35
protein kinase bindingGO:00199013.44
kinase bindingGO:00199003.32
cytoskeletal protein bindingGO:00080923.02
catalytic activityGO:00038241.05
chloride ion bindingGO:00314048.13
peptidase activity, acting on L-amino acid peptidesGO:00700113.26
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
zinc ion bindingGO:00082702.66