| Disease ID | Disease name | Source of annotation with ACSL4 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS309530 | MENTAL RETARDATION, NONSYNDROMIC, X-LINKED | ClinVar, OMIM, HUMSAVAR | link to OMIM | 25 | THOC2, HCFC1, RPS6KA3, USP9X, MID2, RAB39B, KIAA2022, ZNF81, PAK3, IQSEC2, DLG3, TSPAN7, ZDHHC15, ZNF711, KIF4A, ACSL4, BRWD3, IL1RAPL1, GDI1, SYP, ARHGEF6, ARX, DDX3X, GRIA3, FTSJ1 |
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| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| PPAR signaling pathway | hsa03320 | 6.56 |
| Metabolic pathways | hsa01100 | 2.49 |
| Fatty acid biosynthesis | hsa00061 | 8.96 |
| Fatty acid degradation | hsa00071 | 7.15 |
| Peroxisome | hsa04146 | 6.34 |
| Fatty acid metabolism | hsa01212 | 7.07 |
| Adipocytokine signaling pathway | hsa04920 | 6.6 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Triglyceride Biosynthesis | R-HSA-75109 | 7.46 |
| Fatty Acyl-CoA Biosynthesis | R-HSA-75105 | 8.34 |
| Synthesis of very long-chain fatty acyl-CoAs | R-HSA-75876 | 8.66 |
| Metabolism | R-HSA-1430728 | 2.34 |
| Fatty acid, triacylglycerol, and ketone body metabolism | R-HSA-535734 | 5.44 |
| Metabolism of lipids and lipoproteins | R-HSA-556833 | 3.79 |
| GO term | GO ID | GO IC |
|---|---|---|
| fatty acid ligase activity | GO:0015645 | 6.97 |
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| very long-chain fatty acid-CoA ligase activity | GO:0031957 | 7.44 |
| binding | GO:0005488 | 0.18 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| nucleoside binding | GO:0001882 | 2.21 |
| nucleotide binding | GO:0000166 | 1.96 |
| long-chain fatty acid-CoA ligase activity | GO:0004467 | 7.17 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| ATP binding | GO:0005524 | 2.43 |
| GO:0047676 | 9.74 | |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| ligase activity | GO:0016874 | 3.72 |
| ligase activity, forming carbon-sulfur bonds | GO:0016877 | 6.05 |
| acid-thiol ligase activity | GO:0016878 | 6.74 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |