Gene table of ADAM17 : ADAM metallopeptidase domain 17

Gene-disease associations table

Disease IDDisease nameSource of annotation with ADAM17OMIM linkNumber of associated genesgenes
PS614328NEONATAL INFLAMMATORY SKIN AND BOWEL DISEASEOMIM link to OMIM 2EGFR, ADAM17

Download the gene annotation in CSV format

Annotation of the gene ADAM17

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Epithelial cell signaling in Helicobacter pylori infectionhsa051206.58
Notch signaling pathwayhsa043307.12
Alzheimer's diseasehsa050105.34
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by HedgehogR-HSA-53583515.79
Immune SystemR-HSA-1682562.37
Signaling by NOTCHR-HSA-1571186.2
Cytokine Signaling in Immune systemR-HSA-12802153.74
Extracellular matrix organizationR-HSA-14742444.91
p75 NTR receptor-mediated signallingR-HSA-1937046.59
Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantR-HSA-266082610.18
Signaling by ERBB4R-HSA-12363944.7
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation MutantR-HSA-266082510.18
Collagen degradationR-HSA-14424907.03
DiseaseR-HSA-16436853.33
Signalling by NGFR-HSA-1665204.23
Growth hormone receptor signalingR-HSA-9827728.4
Degradation of the extracellular matrixR-HSA-14742286.11
Death Receptor SignallingR-HSA-738878.52
Constitutive Signaling by NOTCH1 HD+PEST Domain MutantsR-HSA-28948627.15
Release of Hh-Np from the secreting cellR-HSA-53627989.98
Constitutive Signaling by NOTCH1 HD Domain MutantsR-HSA-26912329.08
Signaling by NOTCH1 HD Domain Mutants in CancerR-HSA-26912309.08
Diseases of signal transductionR-HSA-56632024.89
Hedgehog ligand biogenesisR-HSA-53583466.98
TNF signalingR-HSA-758939.08
Activated NOTCH1 Transmits Signal to the NucleusR-HSA-21229488.08
Signaling by EGFRR-HSA-1779294.59
Nuclear signaling by ERBB4R-HSA-12519857.7
Regulated proteolysis of p75NTRR-HSA-1936929.66
Signaling by NOTCH1R-HSA-19801436.81
Signaling by NOTCH1 in CancerR-HSA-26446037.15
Signaling by NOTCH1 PEST Domain Mutants in CancerR-HSA-26446027.15
Constitutive Signaling by NOTCH1 PEST Domain MutantsR-HSA-26446067.15
Signaling by NOTCH1 HD+PEST Domain Mutants in CancerR-HSA-28948587.15
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
cytokine receptor bindingGO:00051264.14
endopeptidase activityGO:00041753.63
integrin bindingGO:00051785.07
SH3 domain bindingGO:00171244.98
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
peptidase activityGO:00082333.23
metallopeptidase activityGO:00082374.5
cation bindingGO:00431691.4
transition metal ion bindingGO:00469142.48
ion bindingGO:00431671.36
protein complex bindingGO:00324033.09
metal ion bindingGO:00468721.41
Notch bindingGO:00051126.85
hydrolase activityGO:00167871.9
metalloendopeptidase activityGO:00042225.02
interleukin-6 receptor bindingGO:00051387.79
catalytic activityGO:00038241.05
PDZ domain bindingGO:00301655.22
protein domain specific bindingGO:00199043.32
cell adhesion molecule bindingGO:00508394.5
growth factor receptor bindingGO:00708514.87
peptidase activity, acting on L-amino acid peptidesGO:00700113.26
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
zinc ion bindingGO:00082702.66