Gene table of AKR1C2 : aldo-keto reductase family 1 member C2

Gene-disease associations table

Disease IDDisease nameSource of annotation with AKR1C2OMIM linkNumber of associated genesgenes
PS40004446,XY SEX REVERSALClinVar, OMIM, HUMSAVAR link to OMIM 9AKR1C2, AKR1C4, NR0B1, SRY, MAP3K1, CBX2, NR5A1, DHH, ZFPM2

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Annotation of the gene AKR1C2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation

The gene is in the tandem Group 455, together with the genes:

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Metabolism of xenobiotics by cytochrome P450hsa009806.48
Steroid hormone biosynthesishsa001406.93
Chemical carcinogenesishsa052046.36
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Bile acid and bile salt metabolismR-HSA-1940687.85
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolR-HSA-1933688.4
Synthesis of bile acids and bile salts via 27-hydroxycholesterolR-HSA-1938079.08
Synthesis of bile acids and bile salts via 24-hydroxycholesterolR-HSA-1937759.18
MetabolismR-HSA-14307282.34
Synthesis of bile acids and bile saltsR-HSA-1921058.23
Metabolism of lipids and lipoproteinsR-HSA-5568333.79
Associated GO terms for Molecular function
GO termGO IDGO IC
aldo-keto reductase (NADP) activityGO:00040336.48
GO:00040327.79
monooxygenase activityGO:00044975.1
alcohol dehydrogenase (NADP+) activityGO:00081066.97
GO:00470269.74
bindingGO:00054880.18
GO:00470238.35
oxidoreductase activityGO:00164913.12
anion bindingGO:00431684.17
oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptorGO:00166286.56
GO:00470868.64
oxidoreductase activity, acting on the CH-CH group of donorsGO:00166275.66
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167054.65
ion bindingGO:00431671.36
steroid dehydrogenase activityGO:00162296.34
GO:00186368.64
lipid bindingGO:00082893.26
bile acid bindingGO:00320527.66
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorGO:00337646.48
GO:00471158.35
catalytic activityGO:00038241.05
steroid bindingGO:00054965.24
monocarboxylic acid bindingGO:00332935.61
oxidoreductase activity, acting on CH-OH group of donorsGO:00166144.83
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorGO:00166165.0
organic cyclic compound bindingGO:00971591.05
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygenGO:00167096.07
carboxylic acid bindingGO:00314064.64
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorGO:00166555.66
oxidoreductase activity, acting on NAD(P)HGO:00166515.13