Gene table of AKR1C4 : aldo-keto reductase family 1 member C4

Gene-disease associations table

Disease IDDisease nameSource of annotation with AKR1C4OMIM linkNumber of associated genesgenes
PS40004446,XY SEX REVERSALClinVar, OMIM link to OMIM 9AKR1C2, AKR1C4, NR0B1, SRY, MAP3K1, CBX2, NR5A1, DHH, ZFPM2

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Annotation of the gene AKR1C4

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation

The gene is in the tandem Group 455, together with the genes:

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
Metabolism of xenobiotics by cytochrome P450hsa009806.48
Metabolic pathwayshsa011002.49
Primary bile acid biosynthesishsa001208.68
Steroid hormone biosynthesishsa001406.93
Associated REACTOME pathways
Retinoid metabolism and transportR-HSA-9756347.59
Bile acid and bile salt metabolismR-HSA-1940687.85
Visual phototransductionR-HSA-21873386.44
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterolR-HSA-1933688.4
Synthesis of bile acids and bile salts via 27-hydroxycholesterolR-HSA-1938079.08
Synthesis of bile acids and bile salts via 24-hydroxycholesterolR-HSA-1937759.18
Synthesis of bile acids and bile saltsR-HSA-1921058.23
Metabolism of lipids and lipoproteinsR-HSA-5568333.79
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
aldo-keto reductase (NADP) activityGO:00040336.48
steroid dehydrogenase activityGO:00162296.34
organic acid transmembrane transporter activityGO:00053424.97
monocarboxylic acid transmembrane transporter activityGO:00080286.18
organic hydroxy compound transmembrane transporter activityGO:19016186.02
oxidoreductase activityGO:00164913.12
bile acid transmembrane transporter activityGO:00151257.03
oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptorGO:00166206.13
lipid transporter activityGO:00053195.03
transporter activityGO:00052152.57
steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorGO:00337646.48
catalytic activityGO:00038241.05
oxidoreductase activity, acting on the aldehyde or oxo group of donorsGO:00169035.87
carboxylic acid transmembrane transporter activityGO:00469434.99
electron carrier activityGO:00090554.97
substrate-specific transmembrane transporter activityGO:00228912.9
substrate-specific transporter activityGO:00228922.72
oxidoreductase activity, acting on CH-OH group of donorsGO:00166144.83
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorGO:00166165.0
oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptorGO:00166555.66
transmembrane transporter activityGO:00228572.82
oxidoreductase activity, acting on NAD(P)HGO:00166515.13