Gene table of ALOX5AP : arachidonate 5-lipoxygenase activating protein

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ALOX5AP	OMIM link	Number of associated genes	genes
601367	STROKE, ISCHEMIC	OMIM	link to OMIM	5	PRKCH, NOS3, ALOX5AP, F5, F2

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Annotation of the gene ALOX5AP

Associated genes in ENSEMBL

ENSG00000132965

Associated proteins - SwissProt Accession ID

P20292

Associated PDB IDs

Cytogenetic Band

13q12.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Synthesis of Lipoxins (LX)	R-HSA-2142700	10.4
Metabolism	R-HSA-1430728	2.34
Synthesis of 5-eicosatetraenoic acids	R-HSA-2142688	10.4
Arachidonic acid metabolism	R-HSA-2142753	7.34
Metabolism of lipids and lipoproteins	R-HSA-556833	3.79
Synthesis of Leukotrienes (LT) and Eoxins (EX)	R-HSA-2142691	8.59

Associated GO terms for Molecular function

GO term	GO ID	GO IC
	GO:0004051	9.05
arachidonic acid binding	GO:0050544	8.13
enzyme binding	GO:0019899	2.27
binding	GO:0005488	0.18
molecular function regulator	GO:0098772	2.51
long-chain fatty acid binding	GO:0036041	7.44
oxidoreductase activity	GO:0016491	3.12
anion binding	GO:0043168	4.17
glutathione transferase activity	GO:0004364	6.18
lyase activity	GO:0016829	4.53
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	GO:0016702	6.44
ion binding	GO:0043167	1.36
leukotriene-C4 synthase activity	GO:0004464	8.64
transferase activity, transferring alkyl or aryl (other than methyl) groups	GO:0016765	5.58
transferase activity	GO:0016740	1.95
fatty acid binding	GO:0005504	6.37
oxidoreductase activity, acting on peroxide as acceptor	GO:0016684	6.0
enzyme regulator activity	GO:0030234	2.85
identical protein binding	GO:0042802	2.63
protein homodimerization activity	GO:0042803	3.16
icosatetraenoic acid binding	GO:0050543	7.95
antioxidant activity	GO:0016209	5.49
lipid binding	GO:0008289	3.26
catalytic activity	GO:0003824	1.05
carbon-sulfur lyase activity	GO:0016846	7.54
monocarboxylic acid binding	GO:0033293	5.61
icosanoid binding	GO:0050542	7.95
oxidoreductase activity, acting on single donors with incorporation of molecular oxygen	GO:0016701	6.41
protein N-terminus binding	GO:0047485	5.11
dioxygenase activity	GO:0051213	5.25
carboxylic acid binding	GO:0031406	4.64
protein binding	GO:0005515	0.46
protein dimerization activity	GO:0046983	2.72
protein heterodimerization activity	GO:0046982	3.64
peroxidase activity	GO:0004601	6.05
glutathione peroxidase activity	GO:0004602	6.85
enzyme activator activity	GO:0008047	3.56