Gene table of AMER1 : APC membrane recruitment protein 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with AMER1OMIM linkNumber of associated genesgenes
300373OSTEOPATHIA STRIATA WITH CRANIAL SCLEROSISClinVar, OMIM link to OMIM 1AMER1

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Annotation of the gene AMER1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
T41 mutants of beta-catenin aren't phosphorylatedR-HSA-53587529.08
Signaling by WntR-HSA-1957214.79
misspliced GSK3beta mutants stabilize beta-cateninR-HSA-53397169.08
S33 mutants of beta-catenin aren't phosphorylatedR-HSA-53587479.08
Diseases of signal transductionR-HSA-56632024.89
S37 mutants of beta-catenin aren't phosphorylatedR-HSA-53587499.08
Degradation of beta-catenin by the destruction complexR-HSA-1952536.64
Signaling by WNT in cancerR-HSA-47912757.89
Beta-catenin phosphorylation cascadeR-HSA-1962998.89
APC truncation mutants have impaired AXIN bindingR-HSA-54673379.18
truncated APC mutants destabilize the destruction complexR-HSA-48397449.18
TCF dependent signaling in response to WNTR-HSA-2016815.36
AXIN missense mutants destabilize the destruction complexR-HSA-54673409.18
S45 mutants of beta-catenin aren't phosphorylatedR-HSA-53587519.08
AXIN mutants destabilize the destruction complex, activating WNT signalingR-HSA-48397359.18
Signal TransductionR-HSA-1625821.78
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complexR-HSA-48397439.08
disassembly of the destruction complex and recruitment of AXIN to the membraneR-HSA-46412628.03
truncations of AMER1 destabilize the destruction complexR-HSA-54673489.18
AMER1 mutants destabilize the destruction complexR-HSA-48397489.18
DiseaseR-HSA-16436853.33
Associated GO terms for Molecular function
GO termGO IDGO IC
beta-catenin destruction complex bindingGO:19047139.05
phosphatidylinositol bindingGO:00350914.47
phospholipid bindingGO:00055433.91
lipid bindingGO:00082893.26
beta-catenin bindingGO:00080135.3
phosphatidylinositol bisphosphate bindingGO:19029365.79
macromolecular complex bindingGO:00448772.61
bindingGO:00054880.18
protein bindingGO:00055150.46
phosphatidylinositol phosphate bindingGO:19019815.05
protein complex bindingGO:00324033.09
phosphatidylinositol-4,5-bisphosphate bindingGO:00055465.81