Gene table of ANKLE2 : ankyrin repeat and LEM domain containing 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with ANKLE2	OMIM link	Number of associated genes	genes
PS251200	MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE	ClinVar, OMIM	link to OMIM	16	CDK5RAP2, CENPE, MCPH1, MFSD2A, ANKLE2, ZNF335, CDK6, ASPM, CASC5, SASS6, STIL, CEP152, CENPJ, PHC1, CEP135, WDR62

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Mitotic Metaphase and Anaphase	R-HSA-2555396	5.45
Initiation of Nuclear Envelope Reformation	R-HSA-2995383	9.28
M Phase	R-HSA-68886	4.87
Cell Cycle, Mitotic	R-HSA-69278	4.16
Mitotic Anaphase	R-HSA-68882	5.46
Cell Cycle	R-HSA-1640170	3.89
Nuclear Envelope Reassembly	R-HSA-2995410	9.28

Associated GO terms for Molecular function

GO term	GO ID	GO IC
protein phosphatase 2A binding	GO:0051721	6.41
protein phosphatase regulator activity	GO:0019888	5.41
enzyme regulator activity	GO:0030234	2.85
enzyme binding	GO:0019899	2.27
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
protein phosphatase type 2A regulator activity	GO:0008601	6.69
molecular function regulator	GO:0098772	2.51
phosphatase regulator activity	GO:0019208	5.26