Gene table of APP : amyloid beta precursor protein

Gene-disease associations table

Disease IDDisease nameSource of annotation with APPOMIM linkNumber of associated genesgenes
104300ALZHEIMER DISEASEClinVar, OMIM, HUMSAVAR link to OMIM 13HFE, PSEN2, ACE, APBB2, APP, A2M, PAXIP1, NOS3, MPO, PLAU, BLMH, PSEN1, SORL1
605714CEREBRAL AMYLOID ANGIOPATHY, APP-RELATEDClinVar, OMIM, HUMSAVAR link to OMIM 1APP

Download the gene annotation in CSV format

Annotation of the gene APP

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Alzheimer's diseasehsa050105.34
Serotonergic synapsehsa047265.84
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
TRIF-mediated TLR3/TLR4 signaling R-HSA-9370616.47
Formyl peptide receptors bind formyl peptides and many other ligandsR-HSA-4444739.81
The NLRP3 inflammasomeR-HSA-8444569.4
Platelet degranulation R-HSA-1146086.68
G alpha (i) signalling eventsR-HSA-4185945.1
Toll Like Receptor 2 (TLR2) CascadeR-HSA-1814386.51
Immune SystemR-HSA-1682562.37
MyD88 dependent cascade initiated on endosomeR-HSA-9751556.68
Peptide ligand-binding receptorsR-HSA-3752765.41
MyD88 cascade initiated on plasma membraneR-HSA-9758716.73
Extracellular matrix organizationR-HSA-14742444.91
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathwaysR-HSA-1689286.7
Lysosome Vesicle BiogenesisR-HSA-4327207.85
Clathrin derived vesicle buddingR-HSA-4218376.85
DiseaseR-HSA-16436853.33
ECM proteoglycansR-HSA-30001786.75
Toll Like Receptor 10 (TLR10) CascadeR-HSA-1681426.73
Platelet activation, signaling and aggregationR-HSA-760025.15
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Toll Like Receptor 3 (TLR3) CascadeR-HSA-1681646.47
Response to elevated platelet cytosolic Ca2+R-HSA-760056.59
Toll-Like Receptors CascadesR-HSA-1688985.91
AmyloidsR-HSA-9772257.37
Toll Like Receptor 4 (TLR4) CascadeR-HSA-1660166.11
ZBP1(DAI) mediated induction of type I IFNsR-HSA-16063228.28
GPCR ligand bindingR-HSA-5007924.19
InflammasomesR-HSA-6223128.89
TRAF6 mediated NF-kB activationR-HSA-9335428.4
Toll Like Receptor TLR6:TLR2 CascadeR-HSA-1681886.56
GPCR downstream signalingR-HSA-3883963.07
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.69
Toll Like Receptor 7/8 (TLR7/8) CascadeR-HSA-1681816.68
Innate Immune SystemR-HSA-1682493.17
Membrane TraffickingR-HSA-1999915.26
TAK1 activates NFkB by phosphorylation and activation of IKKs complexR-HSA-4459898.08
trans-Golgi Network Vesicle BuddingR-HSA-1999926.85
RIP-mediated NFkB activation via ZBP1R-HSA-18104768.59
Cytosolic sensors of pathogen-associated DNA R-HSA-18349496.94
DEx/H-box helicases activate type I IFN and inflammatory cytokines production R-HSA-31349639.28
MyD88-independent TLR3/TLR4 cascade R-HSA-1661666.47
Advanced glycosylation endproduct receptor signalingR-HSA-8794159.28
Vesicle-mediated transportR-HSA-56536564.33
Toll Like Receptor TLR1:TLR2 CascadeR-HSA-1681796.51
Signaling by GPCRR-HSA-3727902.68
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationR-HSA-9751386.72
Toll Like Receptor 5 (TLR5) CascadeR-HSA-1681766.73
G alpha (q) signalling eventsR-HSA-4164765.42
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathwaysR-HSA-1686437.31
MyD88:Mal cascade initiated on plasma membraneR-HSA-1660586.56
Activated TLR4 signallingR-HSA-1660546.27
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Toll Like Receptor 9 (TLR9) CascadeR-HSA-1681386.62
Associated GO terms for Molecular function
GO termGO IDGO IC
peptidase inhibitor activityGO:00304144.55
acetylcholine receptor bindingGO:00331307.66
enzyme bindingGO:00198992.27
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
enzyme inhibitor activityGO:00048573.78
molecular function regulatorGO:00987722.51
heterocyclic compound bindingGO:19013631.06
sulfur compound bindingGO:19016814.32
cation bindingGO:00431691.4
transition metal ion bindingGO:00469142.48
ion bindingGO:00431671.36
metal ion bindingGO:00468721.41
endopeptidase regulator activityGO:00611354.57
identical protein bindingGO:00428022.63
enzyme regulator activityGO:00302342.85
peptidase regulator activityGO:00611344.37
protein domain specific bindingGO:00199043.32
endopeptidase inhibitor activityGO:00048664.6
serine-type endopeptidase inhibitor activityGO:00048675.16
PTB domain bindingGO:00514258.35
heparin bindingGO:00082014.68
growth factor receptor bindingGO:00708514.87
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
glycosaminoglycan bindingGO:00055394.42
protein bindingGO:00055150.46
peptidase activator activityGO:00165046.13
receptor bindingGO:00051022.43
enzyme activator activityGO:00080473.56