Gene table of AURKA : aurora kinase A

Gene-disease associations table

Disease IDDisease nameSource of annotation with AURKAOMIM linkNumber of associated genesgenes
114500COLORECTAL CANCEROMIM link to OMIM 30TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B

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Annotation of the gene AURKA

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Oocyte meiosishsa041145.91
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
APC/C-mediated degradation of cell cycle proteinsR-HSA-1741436.61
Regulation of PLK1 Activity at G2/M TransitionR-HSA-25659426.66
Mitotic G2-G2/M phasesR-HSA-4532746.04
Regulation of mitotic cell cycleR-HSA-4532766.61
Cell Cycle, MitoticR-HSA-692784.16
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1R-HSA-1741786.87
Cell CycleR-HSA-16401703.89
G2/M TransitionR-HSA-692756.06
Associated GO terms for Molecular function
GO termGO IDGO IC
ubiquitin-like protein ligase bindingGO:00443894.15
purine ribonucleoside triphosphate bindingGO:00356392.22
enzyme bindingGO:00198992.27
bindingGO:00054880.18
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
nucleotide bindingGO:00001661.96
protein serine/threonine kinase activityGO:00046743.64
transferase activityGO:00167401.95
protein serine/threonine/tyrosine kinase activityGO:00047126.07
nucleoside phosphate bindingGO:19012651.96
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
protein kinase activityGO:00046723.27
ATP bindingGO:00055242.43
histone serine kinase activityGO:00351747.66
kinase activityGO:00163012.93
histone kinase activityGO:00351736.79
small molecule bindingGO:00360941.89
kinase bindingGO:00199003.32
protein kinase bindingGO:00199013.44
ubiquitin protein ligase bindingGO:00316254.17
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
catalytic activityGO:00038241.05
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
adenyl ribonucleotide bindingGO:00325592.41
protein bindingGO:00055150.46
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19