| Disease ID | Disease name | Source of annotation with AXIN2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 608615 | OLIGODONTIA-COLORECTAL CANCER SYNDROME | ClinVar, OMIM | link to OMIM | 1 | AXIN2 |
| 114500 | COLORECTAL CANCER | OMIM | link to OMIM | 30 | TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
| Endometrial cancer | hsa05213 | 6.81 |
| Colorectal cancer | hsa05210 | 6.52 |
| Pathways in cancer | hsa05200 | 3.98 |
| Basal cell carcinoma | hsa05217 | 6.79 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| formation of the beta-catenin:TCF transactivating complex | R-HSA-201722 | 7.18 |
| degradation of AXIN | R-HSA-4641257 | 7.23 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| binding of TCF/LEF:CTNNB1 to target gene promoters | R-HSA-4411364 | 10.18 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| SMAD binding | GO:0046332 | 5.45 |
| enzyme binding | GO:0019899 | 2.27 |
| ubiquitin protein ligase binding | GO:0031625 | 4.17 |
| ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
| GTPase regulator activity | GO:0030695 | 4.01 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| GTPase activator activity | GO:0005096 | 4.11 |
| beta-catenin binding | GO:0008013 | 5.3 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| armadillo repeat domain binding | GO:0070016 | 7.17 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| I-SMAD binding | GO:0070411 | 7.34 |
| molecular function regulator | GO:0098772 | 2.51 |
| nucleoside-triphosphatase regulator activity | GO:0060589 | 3.92 |
| protein domain specific binding | GO:0019904 | 3.32 |
| enzyme activator activity | GO:0008047 | 3.56 |