Gene table of BMP2 : bone morphogenetic protein 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with BMP2	OMIM link	Number of associated genes	genes
PS235200	HEMOCHROMATOSIS	OMIM	link to OMIM	7	TFR2, HAMP, FTH1, BMP2, HFE2, SLC40A1, HFE
112600	BRACHYDACTYLY, TYPE A2	ClinVar, OMIM	link to OMIM	3	BMP2, GDF5, BMPR1B

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
TGF-beta signaling pathway	hsa04350	6.41
Signaling pathways regulating pluripotency of stem cells	hsa04550	5.6
Hedgehog signaling pathway	hsa04340	7.01
Pathways in cancer	hsa05200	3.98
Basal cell carcinoma	hsa05217	6.79
Hippo signaling pathway	hsa04390	5.37
Cytokine-cytokine receptor interaction	hsa04060	4.67

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Elastic fibre formation	R-HSA-1566948	7.49
Extracellular matrix organization	R-HSA-1474244	4.91
Molecules associated with elastic fibres	R-HSA-2129379	7.73
Signaling by BMP	R-HSA-201451	8.46
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
cytokine activity	GO:0005125	4.34
receptor serine/threonine kinase binding	GO:0033612	7.03
phosphatase regulator activity	GO:0019208	5.26
binding	GO:0005488	0.18
molecular function regulator	GO:0098772	2.51
oxidoreductase activity	GO:0016491	3.12
growth factor activity	GO:0008083	4.66
BMP receptor binding	GO:0070700	7.54
transforming growth factor beta receptor binding	GO:0005160	5.81
phosphatase activator activity	GO:0019211	7.54
enzyme regulator activity	GO:0030234	2.85
SMAD binding	GO:0046332	5.45
catalytic activity	GO:0003824	1.05
receptor binding	GO:0005102	2.43
oxidoreductase activity, acting on CH-OH group of donors	GO:0016614	4.83
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	GO:0016616	5.0
co-receptor binding	GO:0039706	7.54
protein binding	GO:0005515	0.46
protein dimerization activity	GO:0046983	2.72
protein heterodimerization activity	GO:0046982	3.64
retinol dehydrogenase activity	GO:0004745	6.85
transmembrane receptor protein serine/threonine kinase binding	GO:0070696	7.1
enzyme activator activity	GO:0008047	3.56