| Disease ID | Disease name | Source of annotation with BUB1B | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 176430 | PREMATURE CHROMATID SEPARATION TRAIT | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | BUB1B |
| PS257300 | MOSAIC VARIEGATED ANEUPLOIDY SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 2 | CEP57, BUB1B |
| 114500 | COLORECTAL CANCER | OMIM | link to OMIM | 30 | TLR4, RAD54B, PTPRJ, TP53, EP300, PTPN12, ODC1, FLCN, TLR2, BAX, PLA2G2A, AURKA, NRAS, APC, MCC, TRIM28, MLH3, AKT1, MT-CO1, AXIN2, CTNNB1, PDGFRL, PIK3CA, KAT5, DCC, BRAF, CCND1, FGFR3, DLC1, BUB1B |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Cell cycle | hsa04110 | 5.68 |
| HTLV-I infection | hsa05166 | 4.59 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Separation of Sister Chromatids | R-HSA-2467813 | 5.55 |
| Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
| Inactivation of APC/C via direct inhibition of the APC/C complex | R-HSA-141430 | 8.81 |
| Cdc20:Phospho-APC/C mediated degradation of Cyclin A | R-HSA-174184 | 6.87 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| APC/C-mediated degradation of cell cycle proteins | R-HSA-174143 | 6.61 |
| Resolution of Sister Chromatid Cohesion | R-HSA-2500257 | 6.18 |
| Mitotic Metaphase and Anaphase | R-HSA-2555396 | 5.45 |
| Cell Cycle Checkpoints | R-HSA-69620 | 5.64 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpoint | R-HSA-179419 | 6.85 |
| RHO GTPases Activate Formins | R-HSA-5663220 | 6.01 |
| Regulation of APC/C activators between G1/S and early anaphase | R-HSA-176408 | 6.72 |
| APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176409 | 6.81 |
| Regulation of mitotic cell cycle | R-HSA-453276 | 6.61 |
| M Phase | R-HSA-68886 | 4.87 |
| Mitotic Anaphase | R-HSA-68882 | 5.46 |
| Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components | R-HSA-141405 | 8.81 |
| RHO GTPase Effectors | R-HSA-195258 | 4.94 |
| Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins | R-HSA-176814 | 6.79 |
| Mitotic Spindle Checkpoint | R-HSA-69618 | 8.73 |
| APC-Cdc20 mediated degradation of Nek2A | R-HSA-179409 | 8.46 |
| Mitotic Prometaphase | R-HSA-68877 | 6.08 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| binding | GO:0005488 | 0.18 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| nucleoside binding | GO:0001882 | 2.21 |
| nucleotide binding | GO:0000166 | 1.96 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| transferase activity | GO:0016740 | 1.95 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| protein kinase activity | GO:0004672 | 3.27 |
| ATP binding | GO:0005524 | 2.43 |
| kinase activity | GO:0016301 | 2.93 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |