| Disease ID | Disease name | Source of annotation with C5 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 615749 | ECULIZUMAB, POOR RESPONSE TO | OMIM | link to OMIM | 1 | C5 |
| 609536 | COMPLEMENT COMPONENT 5 DEFICIENCY | ClinVar, OMIM | link to OMIM | 1 | C5 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Pertussis | hsa05133 | 6.46 |
| Complement and coagulation cascades | hsa04610 | 6.58 |
| Systemic lupus erythematosus | hsa05322 | 5.95 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Staphylococcus aureus infection | hsa05150 | 6.64 |
| Prion diseases | hsa05020 | 7.48 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| G alpha (i) signalling events | R-HSA-418594 | 5.1 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
| Regulation of Complement cascade | R-HSA-977606 | 8.4 |
| Immune System | R-HSA-168256 | 2.37 |
| Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
| Terminal pathway of complement | R-HSA-166665 | 10.18 |
| Complement cascade | R-HSA-166658 | 5.38 |
| Activation of C3 and C5 | R-HSA-174577 | 10.18 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| chemokine receptor binding | GO:0042379 | 5.7 |
| endopeptidase inhibitor activity | GO:0004866 | 4.6 |
| peptidase inhibitor activity | GO:0030414 | 4.55 |
| chemokine activity | GO:0008009 | 5.87 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| peptidase regulator activity | GO:0061134 | 4.37 |
| receptor binding | GO:0005102 | 2.43 |
| cytokine activity | GO:0005125 | 4.34 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| G-protein coupled receptor binding | GO:0001664 | 4.18 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| molecular function regulator | GO:0098772 | 2.51 |
| endopeptidase regulator activity | GO:0061135 | 4.57 |