| Disease ID | Disease name | Source of annotation with CCL2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 607948 | MYCOBACTERIUM TUBERCULOSIS, SUSCEPTIBILITY TO | OMIM | link to OMIM | 11 | IFNG, TIRAP, CD209, IFNGR1, MC3R, CISH, CCL2, IRGM, SLC11A1, TLR2, SP110 |
| 182940 | NEURAL TUBE DEFECTS, SUSCEPTIBILITY TO | OMIM | link to OMIM | 8 | VANGL2, CELSR1, DACT1, FUZ, T, CCL2, SCRIB, VANGL1 |
| 609423 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO | ClinVar, OMIM | link to OMIM | 16 | HLA-C, IFNG, CCL3, CD209, IL4R, KIR3DL1, CCL2, TLR3, CCR2, CX3CR1, CCL11, CCR5, CXCL12, CCL3L1, CXCR1, IL10 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Rheumatoid arthritis | hsa05323 | 6.05 |
| NOD-like receptor signaling pathway | hsa04621 | 6.88 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| Influenza A | hsa05164 | 5.21 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Malaria | hsa05144 | 7.15 |
| TNF signaling pathway | hsa04668 | 5.96 |
| Chemokine signaling pathway | hsa04062 | 5.19 |
| Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| PERK regulates gene expression | R-HSA-381042 | 8.18 |
| Unfolded Protein Response (UPR) | R-HSA-381119 | 6.56 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
| ATF4 activates genes | R-HSA-380994 | 8.34 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
| Chemokine receptors bind chemokines | R-HSA-380108 | 7.2 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| sulfur compound binding | GO:1901681 | 4.32 |
| cytokine receptor binding | GO:0005126 | 4.14 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| chemokine receptor binding | GO:0042379 | 5.7 |
| chemokine activity | GO:0008009 | 5.87 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| kinase activity | GO:0016301 | 2.93 |
| CCR2 chemokine receptor binding | GO:0031727 | 8.64 |
| glycosaminoglycan binding | GO:0005539 | 4.42 |
| catalytic activity | GO:0003824 | 1.05 |
| transferase activity | GO:0016740 | 1.95 |
| cytokine activity | GO:0005125 | 4.34 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein kinase activity | GO:0004672 | 3.27 |
| G-protein coupled receptor binding | GO:0001664 | 4.18 |
| receptor binding | GO:0005102 | 2.43 |
| CCR chemokine receptor binding | GO:0048020 | 6.21 |
| heparin binding | GO:0008201 | 4.68 |