Gene table of CDC42 : cell division cycle 42

Gene-disease associations table

Disease ID	Disease name	Source of annotation with CDC42	OMIM link	Number of associated genes	genes
616737	TAKENOUCHI-KOSAKI SYNDROME	ClinVar, OMIM	link to OMIM	1	CDC42

Download the gene annotation in CSV format

Annotation of the gene CDC42

Associated genes in ENSEMBL

ENSG00000070831

Associated proteins - SwissProt Accession ID

P60953

Associated PDB IDs

Cytogenetic Band

1p36.12

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

PTTG1

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Salmonella infection	hsa05132	6.29
Shigellosis	hsa05131	6.74
Pathogenic Escherichia coli infection	hsa05130	6.99
Pancreatic cancer	hsa05212	6.56
Renal cell carcinoma	hsa05211	6.6
Tight junction	hsa04530	5.53
Neurotrophin signaling pathway	hsa04722	5.78
Endocytosis	hsa04144	4.92
Focal adhesion	hsa04510	4.92
Chemokine signaling pathway	hsa04062	5.19
VEGF signaling pathway	hsa04370	6.77
Epithelial cell signaling in Helicobacter pylori infection	hsa05120	6.58
Bacterial invasion of epithelial cells	hsa05100	6.34
Proteoglycans in cancer	hsa05205	5.02
Pathways in cancer	hsa05200	3.98
Viral carcinogenesis	hsa05203	5.08
GnRH signaling pathway	hsa04912	6.18
Rap1 signaling pathway	hsa04015	4.97
Adherens junction	hsa04520	6.26
Fc gamma R-mediated phagocytosis	hsa04666	6.21
MAPK signaling pathway	hsa04010	4.63
Non-alcoholic fatty liver disease (NAFLD)	hsa04932	5.51
Regulation of actin cytoskeleton	hsa04810	4.9
T cell receptor signaling pathway	hsa04660	6.01
Ras signaling pathway	hsa04014	4.9
Leukocyte transendothelial migration	hsa04670	5.74
Axon guidance	hsa04360	5.63

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
DCC mediated attractive signaling	R-HSA-418885	9.18
Signaling by Robo receptor	R-HSA-376176	7.98
RHO GTPases Activate WASPs and WAVEs	R-HSA-5663213	7.85
Inactivation of Cdc42 and Rac	R-HSA-428543	9.81
GPVI-mediated activation cascade	R-HSA-114604	7.18
Immune System	R-HSA-168256	2.37
Signaling by Rho GTPases	R-HSA-194315	4.43
CDO in myogenesis	R-HSA-375170	8.12
Factors involved in megakaryocyte development and platelet production	R-HSA-983231	5.88
Adaptive Immune System	R-HSA-1280218	3.19
Developmental Biology	R-HSA-1266738	3.48
RHO GTPases activate PAKs	R-HSA-5627123	8.59
MAPK family signaling cascades	R-HSA-5683057	4.89
Signaling by VEGF	R-HSA-194138	4.66
Platelet activation, signaling and aggregation	R-HSA-76002	5.15
CD28 co-stimulation	R-HSA-389356	7.98
CD28 dependent Vav1 pathway	R-HSA-389359	9.4
Costimulation by the CD28 family	R-HSA-388841	6.56
Myogenesis	R-HSA-525793	8.12
RHO GTPases activate KTN1	R-HSA-5625970	9.52
VEGFA-VEGFR2 Pathway	R-HSA-4420097	4.7
RHO GTPases Activate Formins	R-HSA-5663220	6.01
Fcgamma receptor (FCGR) dependent phagocytosis	R-HSA-2029480	5.07
Regulation of actin dynamics for phagocytic cup formation	R-HSA-2029482	5.23
G alpha (12/13) signalling events	R-HSA-416482	6.75
GPCR downstream signaling	R-HSA-388396	3.07
MAPK6/MAPK4 signaling	R-HSA-5687128	6.54
Innate Immune System	R-HSA-168249	3.17
EPH-Ephrin signaling	R-HSA-2682334	6.43
Signaling by EGFR	R-HSA-177929	4.59
Sema4D in semaphorin signaling	R-HSA-400685	8.23
RHO GTPase Effectors	R-HSA-195258	4.94
Sema4D induced cell migration and growth-cone collapse	R-HSA-416572	8.4
EGFR downregulation	R-HSA-182971	8.28
Signaling by GPCR	R-HSA-372790	2.68
EPHB-mediated forward signaling	R-HSA-3928662	7.62
Rho GTPase cycle	R-HSA-194840	6.04
RHO GTPases activate IQGAPs	R-HSA-5626467	8.34
Semaphorin interactions	R-HSA-373755	6.92
Axon guidance	R-HSA-422475	3.93
Hemostasis	R-HSA-109582	3.98
Signal Transduction	R-HSA-162582	1.78
Netrin-1 signaling	R-HSA-373752	7.59

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
Rho GDP-dissociation inhibitor binding	GO:0051022	8.35
GDP-dissociation inhibitor binding	GO:0051021	8.35
binding	GO:0005488	0.18
heterocyclic compound binding	GO:1901363	1.06
apolipoprotein A-I receptor binding	GO:0034191	8.35
apolipoprotein receptor binding	GO:0034190	7.79
ubiquitin-like protein transferase activity	GO:0019787	3.69
GTP-dependent protein binding	GO:0030742	6.91
mitogen-activated protein kinase kinase kinase binding	GO:0031435	6.85
pyrophosphatase activity	GO:0016462	3.04
ubiquitin protein ligase activity	GO:0061630	4.47
nucleotide binding	GO:0000166	1.96
guanyl ribonucleotide binding	GO:0032561	3.73
transferase activity	GO:0016740	1.95
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
nucleoside binding	GO:0001882	2.21
identical protein binding	GO:0042802	2.63
GTP binding	GO:0005525	3.78
hydrolase activity	GO:0016787	1.9
GTPase activity	GO:0003924	4.31
nucleoside-triphosphatase activity	GO:0017111	3.09
nucleoside phosphate binding	GO:1901265	1.96
protein kinase binding	GO:0019901	3.44
catalytic activity	GO:0003824	1.05
ubiquitin-protein transferase activity	GO:0004842	3.73
ubiquitin-like protein ligase activity	GO:0061659	4.44
small molecule binding	GO:0036094	1.89
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
thioesterase binding	GO:0031996	7.25
kinase binding	GO:0019900	3.32
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
guanyl nucleotide binding	GO:0019001	3.73
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19