| Disease ID | Disease name | Source of annotation with CDK6 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS251200 | MICROCEPHALY, PRIMARY AUTOSOMAL RECESSIVE | ClinVar, OMIM, HUMSAVAR | link to OMIM | 16 | CDK5RAP2, CENPE, MCPH1, MFSD2A, ANKLE2, ZNF335, CDK6, ASPM, CASC5, SASS6, STIL, CEP152, CENPJ, PHC1, CEP135, WDR62 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Melanoma | hsa05218 | 6.56 |
| Small cell lung cancer | hsa05222 | 6.17 |
| Pancreatic cancer | hsa05212 | 6.56 |
| Cell cycle | hsa04110 | 5.68 |
| MicroRNAs in cancer | hsa05206 | 5.38 |
| Pathways in cancer | hsa05200 | 3.98 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| p53 signaling pathway | hsa04115 | 6.56 |
| Non-small cell lung cancer | hsa05223 | 6.88 |
| Glioma | hsa05214 | 6.66 |
| Chronic myeloid leukemia | hsa05220 | 6.48 |
| Hepatitis B | hsa05161 | 5.52 |
| Measles | hsa05162 | 5.6 |
| PI3K-Akt signaling pathway | hsa04151 | 4.21 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Oncogene Induced Senescence | R-HSA-2559585 | 8.03 |
| Mitotic G1-G1/S phases | R-HSA-453279 | 5.91 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 6.51 |
| Cellular Senescence | R-HSA-2559583 | 5.7 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 6.77 |
| Cellular responses to stress | R-HSA-2262752 | 4.56 |
| G1 Phase | R-HSA-69236 | 7.73 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| Cyclin D associated events in G1 | R-HSA-69231 | 7.73 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| GO term | GO ID | GO IC |
|---|---|---|
| purine ribonucleoside triphosphate binding | GO:0035639 | 2.22 |
| binding | GO:0005488 | 0.18 |
| cyclin-dependent protein serine/threonine kinase activity | GO:0004693 | 6.21 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| nucleoside phosphate binding | GO:1901265 | 1.96 |
| nucleoside binding | GO:0001882 | 2.21 |
| protein serine/threonine kinase activity | GO:0004674 | 3.64 |
| nucleotide binding | GO:0000166 | 1.96 |
| cyclin-dependent protein kinase activity | GO:0097472 | 6.21 |
| transferase activity | GO:0016740 | 1.95 |
| purine nucleoside binding | GO:0001883 | 2.22 |
| ribonucleoside binding | GO:0032549 | 2.22 |
| purine nucleotide binding | GO:0017076 | 2.19 |
| ATP binding | GO:0005524 | 2.43 |
| kinase activity | GO:0016301 | 2.93 |
| cyclin binding | GO:0030332 | 6.74 |
| protein kinase activity | GO:0004672 | 3.27 |
| small molecule binding | GO:0036094 | 1.89 |
| catalytic activity | GO:0003824 | 1.05 |
| adenyl nucleotide binding | GO:0030554 | 2.4 |
| carbohydrate derivative binding | GO:0097367 | 2.03 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| phosphotransferase activity, alcohol group as acceptor | GO:0016773 | 3.08 |
| adenyl ribonucleotide binding | GO:0032559 | 2.41 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| purine ribonucleotide binding | GO:0032555 | 2.2 |
| purine ribonucleoside binding | GO:0032550 | 2.22 |
| ribonucleotide binding | GO:0032553 | 2.19 |