| Disease ID | Disease name | Source of annotation with CDKN2A | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS155600 | MELANOMA, CUTANEOUS MALIGNANT | ClinVar, OMIM, HUMSAVAR | link to OMIM | 11 | STK11, POT1, BRAF, TERT, PTEN, CDKN2A, MITF, TYR, MC1R, CDK4, XRCC3 |
| PS151623 | LI-FRAUMENI SYNDROME | HUMSAVAR | link to OMIM | 3 | TP53, CHEK2, CDKN2A |
| 155755 | MELANOMA-ASTROCYTOMA SYNDROME | OMIM | link to OMIM | 1 | CDKN2A |
| 606719 | MELANOMA-PANCREATIC CANCER SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CDKN2A |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Melanoma | hsa05218 | 6.56 |
| Bladder cancer | hsa05219 | 7.38 |
| Pancreatic cancer | hsa05212 | 6.56 |
| Cell cycle | hsa04110 | 5.68 |
| MicroRNAs in cancer | hsa05206 | 5.38 |
| Pathways in cancer | hsa05200 | 3.98 |
| Viral carcinogenesis | hsa05203 | 5.08 |
| p53 signaling pathway | hsa04115 | 6.56 |
| Non-small cell lung cancer | hsa05223 | 6.88 |
| Glioma | hsa05214 | 6.66 |
| Chronic myeloid leukemia | hsa05220 | 6.48 |
| HTLV-I infection | hsa05166 | 4.59 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Oncogene Induced Senescence | R-HSA-2559585 | 8.03 |
| Mitotic G1-G1/S phases | R-HSA-453279 | 5.91 |
| Cyclin D associated events in G1 | R-HSA-69231 | 7.73 |
| Cellular Senescence | R-HSA-2559583 | 5.7 |
| Senescence-Associated Secretory Phenotype (SASP) | R-HSA-2559582 | 6.77 |
| SUMO E3 ligases SUMOylate target proteins | R-HSA-3108232 | 6.77 |
| Cellular responses to stress | R-HSA-2262752 | 4.56 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| G1 Phase | R-HSA-69236 | 7.73 |
| Cell Cycle, Mitotic | R-HSA-69278 | 4.16 |
| SUMOylation | R-HSA-2990846 | 6.68 |
| SUMOylation of DNA damage response and repair proteins | R-HSA-3108214 | 6.77 |
| Cell Cycle | R-HSA-1640170 | 3.89 |
| Post-translational protein modification | R-HSA-597592 | 4.54 |
| Oxidative Stress Induced Senescence | R-HSA-2559580 | 6.51 |
| GO term | GO ID | GO IC |
|---|---|---|
| kinase regulator activity | GO:0019207 | 4.5 |
| enzyme binding | GO:0019899 | 2.27 |
| binding | GO:0005488 | 0.18 |
| nucleic acid binding | GO:0003676 | 1.44 |
| DNA binding | GO:0003677 | 1.92 |
| enzyme inhibitor activity | GO:0004857 | 3.78 |
| molecular function regulator | GO:0098772 | 2.51 |
| ubiquitin-protein transferase inhibitor activity | GO:0055105 | 9.05 |
| ligase regulator activity | GO:0055103 | 7.1 |
| ubiquitin-protein transferase regulator activity | GO:0055106 | 7.17 |
| ubiquitin-like protein transferase activity | GO:0019787 | 3.69 |
| MDM2/MDM4 family protein binding | GO:0097371 | 7.95 |
| cyclin-dependent protein serine/threonine kinase inhibitor activity | GO:0004861 | 7.25 |
| heterocyclic compound binding | GO:1901363 | 1.06 |
| cyclin-dependent protein serine/threonine kinase regulator activity | GO:0016538 | 6.41 |
| transferase activity | GO:0016740 | 1.95 |
| enzyme regulator activity | GO:0030234 | 2.85 |
| kinase inhibitor activity | GO:0019210 | 5.25 |
| protein kinase regulator activity | GO:0019887 | 4.6 |
| poly(A) RNA binding | GO:0044822 | 2.69 |
| kinase activity | GO:0016301 | 2.93 |
| transcription factor binding | GO:0008134 | 3.46 |
| NF-kappaB binding | GO:0051059 | 6.34 |
| protein kinase binding | GO:0019901 | 3.44 |
| catalytic activity | GO:0003824 | 1.05 |
| SUMO transferase activity | GO:0019789 | 7.03 |
| protein serine/threonine kinase inhibitor activity | GO:0030291 | 6.34 |
| protein kinase inhibitor activity | GO:0004860 | 5.28 |
| kinase binding | GO:0019900 | 3.32 |
| organic cyclic compound binding | GO:0097159 | 1.05 |
| RNA binding | GO:0003723 | 2.36 |
| protein binding | GO:0005515 | 0.46 |
| transferase activity, transferring phosphorus-containing groups | GO:0016772 | 2.77 |
| p53 binding | GO:0002039 | 5.53 |