Gene table of CXCL12 : C-X-C motif chemokine ligand 12

Gene-disease associations table

Disease IDDisease nameSource of annotation with CXCL12OMIM linkNumber of associated genesgenes
609423HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TOClinVar, OMIM link to OMIM 16HLA-C, IFNG, CCL3, CD209, IL4R, KIR3DL1, CCL2, TLR3, CCR2, CX3CR1, CCL11, CCR5, CXCL12, CCL3L1, CXCR1, IL10

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Annotation of the gene CXCL12

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Rheumatoid arthritishsa053236.05
Pathways in cancerhsa052003.98
Intestinal immune network for IgA productionhsa046726.79
Leukocyte transendothelial migrationhsa046705.74
Axon guidancehsa043605.63
NF-kappa B signaling pathwayhsa040646.21
Chemokine signaling pathwayhsa040625.19
Cytokine-cytokine receptor interactionhsa040604.67
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by GPCRR-HSA-3727902.68
GPCR downstream signalingR-HSA-3883963.07
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.69
Peptide ligand-binding receptorsR-HSA-3752765.41
Signal TransductionR-HSA-1625821.78
Chemokine receptors bind chemokinesR-HSA-3801087.2
G alpha (i) signalling eventsR-HSA-4185945.1
Signaling by ERBB4R-HSA-12363944.7
GPCR ligand bindingR-HSA-5007924.19
Nuclear signaling by ERBB4R-HSA-12519857.7
Associated GO terms for Molecular function
GO termGO IDGO IC
cytokine receptor bindingGO:00051264.14
chemoattractant activityGO:00420566.48
cytokine activityGO:00051254.34
growth factor activityGO:00080834.66
chemokine activityGO:00080095.87
chemokine receptor bindingGO:00423795.7
bindingGO:00054880.18
protein bindingGO:00055150.46
CXCR chemokine receptor bindingGO:00452366.97
G-protein coupled receptor bindingGO:00016644.18
receptor bindingGO:00051022.43