Gene table of CXCL12 : C-X-C motif chemokine ligand 12

Gene-disease associations table

Disease ID	Disease name	Source of annotation with CXCL12	OMIM link	Number of associated genes	genes
609423	HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO	ClinVar, OMIM	link to OMIM	16	HLA-C, IFNG, CCL3, CD209, IL4R, KIR3DL1, CCL2, TLR3, CCR2, CX3CR1, CCL11, CCR5, CXCL12, CCL3L1, CXCR1, IL10

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Rheumatoid arthritis	hsa05323	6.05
Pathways in cancer	hsa05200	3.98
Intestinal immune network for IgA production	hsa04672	6.79
Leukocyte transendothelial migration	hsa04670	5.74
Axon guidance	hsa04360	5.63
NF-kappa B signaling pathway	hsa04064	6.21
Chemokine signaling pathway	hsa04062	5.19
Cytokine-cytokine receptor interaction	hsa04060	4.67

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by GPCR	R-HSA-372790	2.68
GPCR downstream signaling	R-HSA-388396	3.07
Class A/1 (Rhodopsin-like receptors)	R-HSA-373076	4.69
Peptide ligand-binding receptors	R-HSA-375276	5.41
Signal Transduction	R-HSA-162582	1.78
Chemokine receptors bind chemokines	R-HSA-380108	7.2
G alpha (i) signalling events	R-HSA-418594	5.1
Signaling by ERBB4	R-HSA-1236394	4.7
GPCR ligand binding	R-HSA-500792	4.19
Nuclear signaling by ERBB4	R-HSA-1251985	7.7

Associated GO terms for Molecular function

GO term	GO ID	GO IC
cytokine receptor binding	GO:0005126	4.14
chemoattractant activity	GO:0042056	6.48
cytokine activity	GO:0005125	4.34
growth factor activity	GO:0008083	4.66
chemokine activity	GO:0008009	5.87
chemokine receptor binding	GO:0042379	5.7
binding	GO:0005488	0.18
protein binding	GO:0005515	0.46
CXCR chemokine receptor binding	GO:0045236	6.97
G-protein coupled receptor binding	GO:0001664	4.18
receptor binding	GO:0005102	2.43