Disease ID | Disease name | Source of annotation with CXCL12 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
609423 | HUMAN IMMUNODEFICIENCY VIRUS TYPE 1, SUSCEPTIBILITY TO | ClinVar, OMIM | link to OMIM | 16 | HLA-C, IFNG, CCL3, CD209, IL4R, KIR3DL1, CCL2, TLR3, CCR2, CX3CR1, CCL11, CCR5, CXCL12, CCL3L1, CXCR1, IL10 |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Rheumatoid arthritis | hsa05323 | 6.05 |
Pathways in cancer | hsa05200 | 3.98 |
Intestinal immune network for IgA production | hsa04672 | 6.79 |
Leukocyte transendothelial migration | hsa04670 | 5.74 |
Axon guidance | hsa04360 | 5.63 |
NF-kappa B signaling pathway | hsa04064 | 6.21 |
Chemokine signaling pathway | hsa04062 | 5.19 |
Cytokine-cytokine receptor interaction | hsa04060 | 4.67 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Signaling by GPCR | R-HSA-372790 | 2.68 |
GPCR downstream signaling | R-HSA-388396 | 3.07 |
Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
Signal Transduction | R-HSA-162582 | 1.78 |
Chemokine receptors bind chemokines | R-HSA-380108 | 7.2 |
G alpha (i) signalling events | R-HSA-418594 | 5.1 |
Signaling by ERBB4 | R-HSA-1236394 | 4.7 |
GPCR ligand binding | R-HSA-500792 | 4.19 |
Nuclear signaling by ERBB4 | R-HSA-1251985 | 7.7 |
GO term | GO ID | GO IC |
---|---|---|
cytokine receptor binding | GO:0005126 | 4.14 |
chemoattractant activity | GO:0042056 | 6.48 |
cytokine activity | GO:0005125 | 4.34 |
growth factor activity | GO:0008083 | 4.66 |
chemokine activity | GO:0008009 | 5.87 |
chemokine receptor binding | GO:0042379 | 5.7 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
CXCR chemokine receptor binding | GO:0045236 | 6.97 |
G-protein coupled receptor binding | GO:0001664 | 4.18 |
receptor binding | GO:0005102 | 2.43 |