| Disease ID | Disease name | Source of annotation with CYLD | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 605041 | BROOKE-SPIEGLER SYNDROME | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CYLD |
| 601606 | TRICHOEPITHELIOMA, MULTIPLE FAMILIAL, 1 | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | CYLD |
| 132700 | CYLINDROMATOSIS, FAMILIAL | ClinVar, OMIM | link to OMIM | 1 | CYLD |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| RIG-I-like receptor signaling pathway | hsa04622 | 6.62 |
| Osteoclast differentiation | hsa04380 | 5.64 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Innate Immune System | R-HSA-168249 | 3.17 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 9.28 |
| Immune System | R-HSA-168256 | 2.37 |
| Death Receptor Signalling | R-HSA-73887 | 8.52 |
| Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways | R-HSA-168643 | 7.31 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| TNF signaling | R-HSA-75893 | 9.08 |
| NOD1/2 Signaling Pathway | R-HSA-168638 | 7.85 |
| Negative regulators of RIG-I/MDA5 signaling | R-HSA-936440 | 7.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| proline-rich region binding | GO:0070064 | 6.79 |
| thiol-dependent ubiquitin-specific protease activity | GO:0004843 | 5.43 |
| transition metal ion binding | GO:0046914 | 2.48 |
| catalytic activity | GO:0003824 | 1.05 |
| metal ion binding | GO:0046872 | 1.41 |
| ubiquitinyl hydrolase activity | GO:0101005 | 5.07 |
| cation binding | GO:0043169 | 1.4 |
| enzyme binding | GO:0019899 | 2.27 |
| ion binding | GO:0043167 | 1.36 |
| protein kinase binding | GO:0019901 | 3.44 |
| kinase binding | GO:0019900 | 3.32 |
| thiol-dependent ubiquitinyl hydrolase activity | GO:0036459 | 5.07 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| ubiquitin-like protein-specific protease activity | GO:0019783 | 4.97 |
| peptidase activity | GO:0008233 | 3.23 |
| Lys63-specific deubiquitinase activity | GO:0061578 | 8.64 |
| cysteine-type peptidase activity | GO:0008234 | 4.51 |
| zinc ion binding | GO:0008270 | 2.66 |