Gene table of CYP17A1 : cytochrome P450 family 17 subfamily A member 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with CYP17A1OMIM linkNumber of associated genesgenes
202110ADRENAL HYPERPLASIA, CONGENITAL, DUE TO 17-ALPHA-HYDROXYLASE DEFICIENCYClinVar, OMIM, HUMSAVAR link to OMIM 1CYP17A1

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Annotation of the gene CYP17A1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Ovarian steroidogenesishsa049137.07
Metabolic pathwayshsa011002.49
Steroid hormone biosynthesishsa001406.93
Prolactin signaling pathwayhsa049176.6
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Glucocorticoid biosynthesisR-HSA-1940029.81
Phase 1 - Functionalization of compoundsR-HSA-2119456.7
Metabolism of steroid hormones and vitamin DR-HSA-1960717.89
Biological oxidationsR-HSA-2118595.55
Cytochrome P450 - arranged by substrate typeR-HSA-2118977.08
Diseases of metabolismR-HSA-56689146.57
Endogenous sterolsR-HSA-2119768.46
MetabolismR-HSA-14307282.34
DiseaseR-HSA-16436853.33
Metabolism of lipids and lipoproteinsR-HSA-5568333.79
Androgen biosynthesisR-HSA-1930489.52
Metabolic disorders of biological oxidation enzymesR-HSA-55790297.85
Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)R-HSA-557902812.98
Associated GO terms for Molecular function
GO termGO IDGO IC
oxidoreductase activityGO:00164913.12
cation bindingGO:00431691.4
monooxygenase activityGO:00044975.1
oxygen bindingGO:00198255.89
heme bindingGO:00200374.86
transition metal ion bindingGO:00469142.48
metal ion bindingGO:00468721.41
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGO:00167054.65
organic cyclic compound bindingGO:00971591.05
lyase activityGO:00168294.53
tetrapyrrole bindingGO:00469064.8
carbon-carbon lyase activityGO:00168305.81
aldehyde-lyase activityGO:00168327.54
steroid 17-alpha-monooxygenase activityGO:00045089.74
catalytic activityGO:00038241.05
bindingGO:00054880.18
steroid hydroxylase activityGO:00083956.3
iron ion bindingGO:00055064.65
ion bindingGO:00431671.36
heterocyclic compound bindingGO:19013631.06
17-alpha-hydroxyprogesterone aldolase activityGO:00474429.74