Gene table of DDX41 : DEAD-box helicase 41

Gene-disease associations table

Disease ID	Disease name	Source of annotation with DDX41	OMIM link	Number of associated genes	genes
601626	LEUKEMIA, ACUTE MYELOID	ClinVar	link to OMIM	23	FLT3, RUNX1, WHSC1L1, KIT, MLF1, CHIC2, CEBPA, LPP, SH3GL1, PICALM, NPM1, CBFB, ETV6, SETBP1, MLLT10, TERT, NUP214, JAK2, GATA2, TGM6, DDX41, NSD1, KRAS
616871	MYELOPROLIFERATIVE/LYMPHOPROLIFERATIVE NEOPLASMS, FAMILIAL (MULTIPLE TYPES), SUSCEPTIBILITY TO	ClinVar, OMIM	link to OMIM	1	DDX41

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Annotation of the gene DDX41

Associated genes in ENSEMBL

ENSG00000183258

Associated proteins - SwissProt Accession ID

Q9UJV9

Associated PDB IDs

2p6n

Cytogenetic Band

5q35.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
IRF3-mediated induction of type I IFN	R-HSA-3270619	9.28
Regulation of innate immune responses to cytosolic DNA	R-HSA-3134975	9.08
Immune System	R-HSA-168256	2.37
Innate Immune System	R-HSA-168249	3.17
Cytosolic sensors of pathogen-associated DNA	R-HSA-1834949	6.94
STING mediated induction of host immune responses	R-HSA-1834941	8.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ATPase activity	GO:0016887	3.65
ATP-dependent helicase activity	GO:0008026	5.12
purine ribonucleoside triphosphate binding	GO:0035639	2.22
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
RNA-dependent ATPase activity	GO:0008186	5.56
nucleotide binding	GO:0000166	1.96
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
pyrophosphatase activity	GO:0016462	3.04
ion binding	GO:0043167	1.36
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
ATP binding	GO:0005524	2.43
hydrolase activity	GO:0016787	1.9
poly(A) RNA binding	GO:0044822	2.69
nucleoside-triphosphatase activity	GO:0017111	3.09
ATP-dependent RNA helicase activity	GO:0004004	5.56
helicase activity	GO:0004386	4.69
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
ATPase activity, coupled	GO:0042623	3.97
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
purine NTP-dependent helicase activity	GO:0070035	5.12
RNA helicase activity	GO:0003724	5.53
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19