| Disease ID | Disease name | Source of annotation with DVL3 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| PS268310 | ROBINOW SYNDROME | ClinVar, OMIM | link to OMIM | 4 | WNT5A, ROR2, DVL1, DVL3 |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
| Pathways in cancer | hsa05200 | 3.98 |
| Basal cell carcinoma | hsa05217 | 6.79 |
| Notch signaling pathway | hsa04330 | 7.12 |
| Melanogenesis | hsa04916 | 5.97 |
| Hippo signaling pathway | hsa04390 | 5.37 |
| HTLV-I infection | hsa05166 | 4.59 |
| Wnt signaling pathway | hsa04310 | 5.49 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| disassembly of the destruction complex and recruitment of AXIN to the membrane | R-HSA-4641262 | 8.03 |
| RHO GTPases Activate Formins | R-HSA-5663220 | 6.01 |
| beta-catenin independent WNT signaling | R-HSA-3858494 | 5.83 |
| Signaling by Rho GTPases | R-HSA-194315 | 4.43 |
| negative regulation of TCF-dependent signaling by DVL-interacting proteins | R-HSA-5368598 | 10.66 |
| PCP/CE pathway | R-HSA-4086400 | 6.47 |
| WNT mediated activation of DVL | R-HSA-201688 | 9.98 |
| Signaling by Wnt | R-HSA-195721 | 4.79 |
| RHO GTPase Effectors | R-HSA-195258 | 4.94 |
| TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| degradation of DVL | R-HSA-4641258 | 7.18 |
| GO term | GO ID | GO IC |
|---|---|---|
| beta-catenin binding | GO:0008013 | 5.3 |
| protein binding, bridging | GO:0030674 | 4.68 |
| protein heterodimerization activity | GO:0046982 | 3.64 |
| protein binding | GO:0005515 | 0.46 |
| frizzled binding | GO:0005109 | 6.1 |
| Rac GTPase binding | GO:0048365 | 6.05 |
| enzyme binding | GO:0019899 | 2.27 |
| Ras GTPase binding | GO:0017016 | 4.2 |
| small GTPase binding | GO:0031267 | 4.13 |
| GTPase binding | GO:0051020 | 4.05 |
| Rho GTPase binding | GO:0017048 | 5.36 |
| protease binding | GO:0002020 | 5.08 |
| G-protein coupled receptor binding | GO:0001664 | 4.18 |
| receptor binding | GO:0005102 | 2.43 |
| binding, bridging | GO:0060090 | 4.57 |
| protein dimerization activity | GO:0046983 | 2.72 |
| binding | GO:0005488 | 0.18 |