| Disease ID | Disease name | Source of annotation with EDNRA | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 157300 | MIGRAINE WITH OR WITHOUT AURA, SUSCEPTIBILITY TO, 1 | OMIM | link to OMIM | 3 | EDNRA, ESR1, TNF |
| 616367 | MANDIBULOFACIAL DYSOSTOSIS WITH ALOPECIA | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | EDNRA |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| cGMP-PKG signaling pathway | hsa04022 | 5.32 |
| Calcium signaling pathway | hsa04020 | 5.22 |
| Pathways in cancer | hsa05200 | 3.98 |
| cAMP signaling pathway | hsa04024 | 5.05 |
| Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
| Vascular smooth muscle contraction | hsa04270 | 5.74 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| phosphatidylinositol phospholipase C activity | GO:0004435 | 6.41 |
| signaling receptor activity | GO:0038023 | 2.49 |
| protein binding | GO:0005515 | 0.46 |
| phosphoric diester hydrolase activity | GO:0008081 | 5.23 |
| catalytic activity | GO:0003824 | 1.05 |
| peptide receptor activity | GO:0001653 | 4.84 |
| G-protein coupled receptor activity | GO:0004930 | 2.95 |
| hydrolase activity, acting on ester bonds | GO:0016788 | 3.1 |
| phosphoric ester hydrolase activity | GO:0042578 | 3.82 |
| molecular transducer activity | GO:0060089 | 2.32 |
| transmembrane signaling receptor activity | GO:0004888 | 2.57 |
| phospholipase C activity | GO:0004629 | 6.3 |
| G-protein coupled peptide receptor activity | GO:0008528 | 4.86 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| receptor activity | GO:0004872 | 2.32 |
| phospholipase activity | GO:0004620 | 5.16 |
| lipase activity | GO:0016298 | 4.96 |
| transmembrane receptor activity | GO:0099600 | 2.53 |
| endothelin receptor activity | GO:0004962 | 9.05 |