Gene table of EEF2 : eukaryotic translation elongation factor 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with EEF2	OMIM link	Number of associated genes	genes
PS164400	SPINOCEREBELLAR ATAXIA	ClinVar, OMIM, HUMSAVAR	link to OMIM	31	ATXN10, ATXN2, SCYL1, PDYN, ELOVL5, PRKCG, TRPC3, ATXN8OS, NOP56, ATXN8, TBP, PPP2R2B, ELOVL4, PLEKHG4, ATXN7, AFG3L2, BEAN1, CACNA1A, ATXN1, TTBK2, KCND3, CACNA1G, TMEM240, ATXN3, KCNC3, SPTBN2, TGM6, CCDC88C, FGF14, ITPR1, EEF2

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Annotation of the gene EEF2

Associated genes in ENSEMBL

ENSG00000167658

Associated proteins - SwissProt Accession ID

P13639

Associated PDB IDs

4v6x

Cytogenetic Band

19p13.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
AMPK signaling pathway	hsa04152	5.8
Oxytocin signaling pathway	hsa04921	5.4

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Infectious disease	R-HSA-5663205	4.47
Eukaryotic Translation Elongation	R-HSA-156842	6.52
Peptide chain elongation	R-HSA-156902	6.59
Gamma carboxylation, hypusine formation and arylsulfatase activation	R-HSA-163841	7.81
Synthesis of diphthamide-EEF2	R-HSA-5358493	9.98
Translation	R-HSA-72766	5.8
Metabolism of proteins	R-HSA-392499	3.41
Gene Expression	R-HSA-74160	2.72
Uptake and function of diphtheria toxin	R-HSA-5336415	10.4
Post-translational protein modification	R-HSA-597592	4.54
Uptake and actions of bacterial toxins	R-HSA-5339562	8.28
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
ribonucleoprotein complex binding	GO:0043021	5.15
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
kinase binding	GO:0019900	3.32
pyrophosphatase activity	GO:0016462	3.04
nucleotide binding	GO:0000166	1.96
actin binding	GO:0003779	3.74
guanyl ribonucleotide binding	GO:0032561	3.73
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
ribosome binding	GO:0043022	5.83
GTP binding	GO:0005525	3.78
hydrolase activity	GO:0016787	1.9
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
poly(A) RNA binding	GO:0044822	2.69
translation factor activity, RNA binding	GO:0008135	5.07
GTPase activity	GO:0003924	4.31
nucleoside-triphosphatase activity	GO:0017111	3.09
actin filament binding	GO:0051015	4.93
protein kinase binding	GO:0019901	3.44
catalytic activity	GO:0003824	1.05
small molecule binding	GO:0036094	1.89
5S rRNA binding	GO:0008097	8.35
cytoskeletal protein binding	GO:0008092	3.02
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
rRNA binding	GO:0019843	5.68
guanyl nucleotide binding	GO:0019001	3.73
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
translation elongation factor activity	GO:0003746	6.27
p53 binding	GO:0002039	5.53
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19