Gene table of EGF : epidermal growth factor

Gene-disease associations table

Disease IDDisease nameSource of annotation with EGFOMIM linkNumber of associated genesgenes
PS602014HYPOMAGNESEMIAClinVar, OMIM, HUMSAVAR link to OMIM 6CLDN19, CLDN16, TRPM6, EGF, CNNM2, FXYD2

Download the gene annotation in CSV format

Annotation of the gene EGF

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Melanomahsa052186.56
Bladder cancerhsa052197.38
FoxO signaling pathwayhsa040685.63
Pancreatic cancerhsa052126.56
Endometrial cancerhsa052136.81
Gliomahsa052146.66
Prostate cancerhsa052156.11
Choline metabolism in cancerhsa052316.09
Focal adhesionhsa045104.92
HIF-1 signaling pathwayhsa040665.9
Cytokine-cytokine receptor interactionhsa040604.67
PI3K-Akt signaling pathwayhsa041514.21
Hepatitis Chsa051605.68
Gap junctionhsa045406.24
Pathways in cancerhsa052003.98
Rap1 signaling pathwayhsa040154.97
Ras signaling pathwayhsa040144.9
Non-small cell lung cancerhsa052236.88
ErbB signaling pathwayhsa040126.15
MAPK signaling pathwayhsa040104.63
Regulation of actin cytoskeletonhsa048104.9
Endocytosishsa041444.92
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
PLCG1 events in ERBB2 signalingR-HSA-12519327.85
Platelet degranulation R-HSA-1146086.68
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
Signaling by Ligand-Responsive EGFR Variants in CancerR-HSA-56378158.73
Constitutive Signaling by EGFRvIIIR-HSA-56378109.08
Signaling by EGFRvIII in CancerR-HSA-56378129.08
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Signaling by Overexpressed Wild-Type EGFR in CancerR-HSA-563830211.98
Inhibition of Signaling by Overexpressed EGFRR-HSA-563830311.98
Signaling by EGFRR-HSA-1779294.59
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
PI3K/AKT activationR-HSA-1982036.32
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Frs2-mediated activationR-HSA-1709685.12
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
RAF/MAP kinase cascadeR-HSA-56730015.15
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by EGFR in CancerR-HSA-16437138.73
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
PI3K events in ERBB4 signalingR-HSA-12503426.37
Axon guidanceR-HSA-4224753.93
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Immune SystemR-HSA-1682562.37
Signalling to RASR-HSA-1670445.08
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Signaling by GPCRR-HSA-3727902.68
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
Platelet activation, signaling and aggregationR-HSA-760025.15
Response to elevated platelet cytosolic Ca2+R-HSA-760056.59
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsR-HSA-12363828.73
EGFR interacts with phospholipase C-gammaR-HSA-2127187.89
Signalling by NGFR-HSA-1665204.23
EGFR downregulationR-HSA-1829718.28
Signalling to ERKsR-HSA-1876875.04
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
signaling receptor activityGO:00380232.49
signal transducer activityGO:00048712.28
kinase activator activityGO:00192095.58
guanyl-nucleotide exchange factor activityGO:00050854.02
molecular transducer activityGO:00600892.32
bindingGO:00054880.18
phosphatidylinositol 3-kinase activityGO:00350045.49
molecular function regulatorGO:00987722.51
kinase regulator activityGO:00192074.5
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
cation bindingGO:00431691.4
growth factor activityGO:00080834.66
receptor regulator activityGO:00305455.91
receptor activator activityGO:00305466.27
protein kinase regulator activityGO:00198874.6
ion bindingGO:00431671.36
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
calcium ion bindingGO:00055093.17
protein kinase activityGO:00046723.27
receptor activityGO:00048722.32
metal ion bindingGO:00468721.41
protein tyrosine kinase activityGO:00047134.54
epidermal growth factor receptor bindingGO:00051546.34
enzyme regulator activityGO:00302342.85
kinase activityGO:00163012.93
catalytic activityGO:00038241.05
protein kinase activator activityGO:00302955.68
protein tyrosine kinase activator activityGO:00302966.91
transmembrane receptor protein tyrosine kinase activator activityGO:00302977.95
growth factor receptor bindingGO:00708514.87
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
Wnt-activated receptor activityGO:00428136.65
transmembrane signaling receptor activityGO:00048882.57
protein bindingGO:00055150.46
Wnt-protein bindingGO:00171476.3
receptor bindingGO:00051022.43
transmembrane receptor activityGO:00996002.53
enzyme activator activityGO:00080473.56