Gene table of EIF4A3 : eukaryotic translation initiation factor 4A3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with EIF4A3	OMIM link	Number of associated genes	genes
268305	ROBIN SEQUENCE WITH CLEFT MANDIBLE AND LIMB ANOMALIES	ClinVar, OMIM, HUMSAVAR	link to OMIM	1	EIF4A3

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Annotation of the gene EIF4A3

Associated genes in ENSEMBL

ENSG00000141543

Associated proteins - SwissProt Accession ID

P38919

Associated PDB IDs

Cytogenetic Band

17q25.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
mRNA surveillance pathway	hsa03015	6.28
RNA transport	hsa03013	5.37
Spliceosome	hsa03040	5.73

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Cytokine Signaling in Immune system	R-HSA-1280215	3.74
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	R-HSA-975957	6.25
Gene Expression	R-HSA-74160	2.72
Immune System	R-HSA-168256	2.37
Deadenylation of mRNA	R-HSA-429947	8.46
ISG15 antiviral mechanism	R-HSA-1169408	6.83
Interferon Signaling	R-HSA-913531	4.95
Nonsense-Mediated Decay (NMD)	R-HSA-927802	6.25
Deadenylation-dependent mRNA decay	R-HSA-429914	7.37
Antiviral mechanism by IFN-stimulated genes	R-HSA-1169410	6.83

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ATPase activity	GO:0016887	3.65
ATP-dependent helicase activity	GO:0008026	5.12
purine ribonucleoside triphosphate binding	GO:0035639	2.22
catalytic activity	GO:0003824	1.05
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
RNA-dependent ATPase activity	GO:0008186	5.56
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
single-stranded RNA binding	GO:0003727	5.5
nucleotide binding	GO:0000166	1.96
poly(A) binding	GO:0008143	7.17
nucleoside phosphate binding	GO:1901265	1.96
ribonucleoside binding	GO:0032549	2.22
ribonucleoprotein complex binding	GO:0043021	5.15
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
hydrolase activity	GO:0016787	1.9
selenocysteine insertion sequence binding	GO:0035368	8.35
poly(A) RNA binding	GO:0044822	2.69
nucleoside-triphosphatase activity	GO:0017111	3.09
ATP-dependent RNA helicase activity	GO:0004004	5.56
helicase activity	GO:0004386	4.69
small molecule binding	GO:0036094	1.89
RNA stem-loop binding	GO:0035613	7.44
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
poly-purine tract binding	GO:0070717	6.79
ATPase activity, coupled	GO:0042623	3.97
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
purine NTP-dependent helicase activity	GO:0070035	5.12
RNA helicase activity	GO:0003724	5.53
adenyl ribonucleotide binding	GO:0032559	2.41
RNA binding	GO:0003723	2.36
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
pyrophosphatase activity	GO:0016462	3.04
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
mRNA binding	GO:0003729	4.68