Gene table of ERCC3 : ERCC excision repair 3, TFIIH core complex helicase subunit

Gene-disease associations table

Disease IDDisease nameSource of annotation with ERCC3OMIM linkNumber of associated genesgenes
610651XERODERMA PIGMENTOSUM, COMPLEMENTATION GROUP BClinVar, OMIM, HUMSAVAR link to OMIM 1ERCC3
PS601675TRICHOTHIODYSTROPHYClinVar, OMIM, HUMSAVAR link to OMIM 5ERCC3, MPLKIP, RNF113A, GTF2H5, ERCC2

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Annotation of the gene ERCC3

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is a TF of the genes:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Basal transcription factorshsa030227.31
Nucleotide excision repairhsa034207.15
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Global Genomic NER (GG-NER)R-HSA-1099707.89
Dual incision reaction in TC-NERR-HSA-1103048.12
Formation of transcription-coupled NER (TC-NER) repair complexR-HSA-1103028.12
Transcription-coupled NER (TC-NER)R-HSA-739377.49
Formation of incision complex in GG-NERR-HSA-739358.59
RNA Polymerase I Promoter EscapeR-HSA-737728.08
RNA Polymerase I Chain ElongationR-HSA-737777.18
RNA Polymerase II Promoter EscapeR-HSA-737767.52
RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningR-HSA-737797.52
RNA Polymerase I Promoter ClearanceR-HSA-738546.75
DiseaseR-HSA-16436853.33
RNA Polymerase II Pre-transcription EventsR-HSA-6746957.01
Transcription of the HIV genomeR-HSA-1671726.96
Negative epigenetic regulation of rRNA expressionR-HSA-52509416.75
RNA Polymerase II Transcription Initiation And Promoter ClearanceR-HSA-760427.52
Gene ExpressionR-HSA-741602.72
Formation of the HIV-1 Early Elongation ComplexR-HSA-1671587.94
HIV InfectionR-HSA-1629065.22
Late Phase of HIV Life CycleR-HSA-1625996.02
Nucleotide Excision RepairR-HSA-738857.34
RNA Polymerase II TranscriptionR-HSA-738576.25
Infectious diseaseR-HSA-56632054.47
Epigenetic regulation of gene expressionR-HSA-2121656.46
mRNA CappingR-HSA-720868.12
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionR-HSA-5040466.16
RNA Polymerase II Transcription InitiationR-HSA-759537.52
Dual incision reaction in GG-NERR-HSA-739418.59
HIV Transcription ElongationR-HSA-1671697.59
RNA Polymerase I TranscriptionR-HSA-738646.72
HIV Transcription InitiationR-HSA-1671617.52
RNA Pol II CTD phosphorylation and interaction with CER-HSA-1671608.23
RNA Polymerase I Transcription TerminationR-HSA-738638.03
RNA Polymerase II HIV Promoter EscapeR-HSA-1671627.52
Formation of RNA Pol II elongation complex R-HSA-1123827.56
Formation of HIV elongation complex in the absence of HIV TatR-HSA-1671527.56
Formation of HIV-1 elongation complex containing HIV-1 TatR-HSA-1672007.59
RNA Pol II CTD phosphorylation and interaction with CER-HSA-770758.23
Formation of the Early Elongation ComplexR-HSA-1134187.94
NoRC negatively regulates rRNA expressionR-HSA-4274136.81
DNA RepairR-HSA-738945.8
RNA Polymerase I Transcription InitiationR-HSA-737627.43
Tat-mediated elongation of the HIV-1 transcriptR-HSA-1672467.59
HIV Life CycleR-HSA-1625875.89
RNA Polymerase II Transcription ElongationR-HSA-759557.56
Associated GO terms for Molecular function
GO termGO IDGO IC
protein C-terminus bindingGO:00080224.5
ATPase activityGO:00168873.65
ATP-dependent helicase activityGO:00080265.12
purine ribonucleoside triphosphate bindingGO:00356392.22
bindingGO:00054880.18
nucleic acid bindingGO:00036761.44
DNA bindingGO:00036771.92
DNA helicase activityGO:00036785.73
RNA polymerase II carboxy-terminal domain kinase activityGO:00083536.97
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
peptide bindingGO:00422774.22
guanyl nucleotide bindingGO:00190013.73
nucleotide bindingGO:00001661.96
protein serine/threonine kinase activityGO:00046743.64
transferase activityGO:00167401.95
dATP bindingGO:00325648.35
nucleoside phosphate bindingGO:19012651.96
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
protein kinase activityGO:00046723.27
transcription factor bindingGO:00081343.46
ATP bindingGO:00055242.43
GTP bindingGO:00055253.78
guanyl ribonucleotide bindingGO:00325613.73
hydrolase activityGO:00167871.9
amide bindingGO:00332184.14
deoxyribonucleotide bindingGO:00325527.95
kinase activityGO:00163012.93
nucleoside-triphosphatase activityGO:00171113.09
helicase activityGO:00043864.69
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
DNA-dependent ATPase activityGO:00080945.31
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydridesGO:00168183.03
pyrophosphatase activityGO:00164623.04
protein N-terminus bindingGO:00474855.11
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
ATPase activity, coupledGO:00426233.97
hydrolase activity, acting on acid anhydridesGO:00168173.03
purine ribonucleoside bindingGO:00325502.22
purine NTP-dependent helicase activityGO:00700355.12
adenyl ribonucleotide bindingGO:00325592.41
adenyl deoxyribonucleotide bindingGO:00325588.35
protein bindingGO:00055150.46
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
purine deoxyribonucleotide bindingGO:00325548.13
3'-5' DNA helicase activityGO:00431387.25
damaged DNA bindingGO:00036845.58
ribonucleotide bindingGO:00325532.19
ATP-dependent DNA helicase activityGO:00040036.13