| Disease ID | Disease name | Source of annotation with F2 | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 614390 | PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2 | ClinVar, OMIM | link to OMIM | 1 | F2 |
| 613679 | PROTHROMBIN DEFICIENCY, CONGENITAL | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | F2 |
| 601367 | STROKE, ISCHEMIC | OMIM | link to OMIM | 5 | PRKCH, NOS3, ALOX5AP, F5, F2 |
| PS188050 | THROMBOPHILIA | ClinVar, OMIM | link to OMIM | 13 | HRG, SERPIND1, F5, MTHFR, SERPINC1, THBD, F2, PROS1, PLAT, F9, HABP2, F13A1, PROC |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
| Complement and coagulation cascades | hsa04610 | 6.58 |
| Regulation of actin cytoskeleton | hsa04810 | 4.9 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| Gamma-carboxylation of protein precursors | R-HSA-159740 | 9.81 |
| Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) | R-HSA-381426 | 8.59 |
| Gamma carboxylation, hypusine formation and arylsulfatase activation | R-HSA-163841 | 7.81 |
| Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
| Cell surface interactions at the vascular wall | R-HSA-202733 | 6.32 |
| Gamma-carboxylation, transport, and amino-terminal cleavage of proteins | R-HSA-159854 | 9.52 |
| Post-translational protein modification | R-HSA-597592 | 4.54 |
| Platelet Aggregation (Plug Formation) | R-HSA-76009 | 7.77 |
| Platelet activation, signaling and aggregation | R-HSA-76002 | 5.15 |
| Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
| GPCR ligand binding | R-HSA-500792 | 4.19 |
| GPCR downstream signaling | R-HSA-388396 | 3.07 |
| Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
| Metabolism of proteins | R-HSA-392499 | 3.41 |
| Signaling by GPCR | R-HSA-372790 | 2.68 |
| Thrombin signalling through proteinase activated receptors (PARs) | R-HSA-456926 | 7.98 |
| G alpha (q) signalling events | R-HSA-416476 | 5.42 |
| Hemostasis | R-HSA-109582 | 3.98 |
| Removal of aminoterminal propeptides from gamma-carboxylated proteins | R-HSA-159782 | 9.81 |
| Intrinsic Pathway of Fibrin Clot Formation | R-HSA-140837 | 8.52 |
| Common Pathway of Fibrin Clot Formation | R-HSA-140875 | 8.52 |
| Formation of Fibrin Clot (Clotting Cascade) | R-HSA-140877 | 7.7 |
| Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus | R-HSA-159763 | 9.98 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| hydrolase activity | GO:0016787 | 1.9 |
| metal ion binding | GO:0046872 | 1.41 |
| serine-type endopeptidase activity | GO:0004252 | 4.4 |
| growth factor activity | GO:0008083 | 4.66 |
| protein binding | GO:0005515 | 0.46 |
| serine hydrolase activity | GO:0017171 | 4.26 |
| catalytic activity | GO:0003824 | 1.05 |
| cation binding | GO:0043169 | 1.4 |
| thrombospondin receptor activity | GO:0070053 | 8.35 |
| ion binding | GO:0043167 | 1.36 |
| molecular transducer activity | GO:0060089 | 2.32 |
| peptidase activity, acting on L-amino acid peptides | GO:0070011 | 3.26 |
| binding | GO:0005488 | 0.18 |
| signal transducer activity | GO:0004871 | 2.28 |
| receptor activity | GO:0004872 | 2.32 |
| signaling receptor activity | GO:0038023 | 2.49 |
| receptor binding | GO:0005102 | 2.43 |
| serine-type peptidase activity | GO:0008236 | 4.27 |
| endopeptidase activity | GO:0004175 | 3.63 |
| peptidase activity | GO:0008233 | 3.23 |
| calcium ion binding | GO:0005509 | 3.17 |