Gene table of F2 : coagulation factor II, thrombin

Gene-disease associations table

Disease IDDisease nameSource of annotation with F2OMIM linkNumber of associated genesgenes
614390PREGNANCY LOSS, RECURRENT, SUSCEPTIBILITY TO, 2ClinVar, OMIM link to OMIM 1F2
613679PROTHROMBIN DEFICIENCY, CONGENITALClinVar, OMIM, HUMSAVAR link to OMIM 1F2
601367STROKE, ISCHEMICOMIM link to OMIM 5PRKCH, NOS3, ALOX5AP, F5, F2
PS188050THROMBOPHILIAClinVar, OMIM link to OMIM 13HRG, SERPIND1, F5, MTHFR, SERPINC1, THBD, F2, PROS1, PLAT, F9, HABP2, F13A1, PROC

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Annotation of the gene F2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Neuroactive ligand-receptor interactionhsa040804.58
Complement and coagulation cascadeshsa046106.58
Regulation of actin cytoskeletonhsa048104.9
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Gamma-carboxylation of protein precursorsR-HSA-1597409.81
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)R-HSA-3814268.59
Gamma carboxylation, hypusine formation and arylsulfatase activationR-HSA-1638417.81
Peptide ligand-binding receptorsR-HSA-3752765.41
Cell surface interactions at the vascular wallR-HSA-2027336.32
Gamma-carboxylation, transport, and amino-terminal cleavage of proteinsR-HSA-1598549.52
Post-translational protein modificationR-HSA-5975924.54
Platelet Aggregation (Plug Formation)R-HSA-760097.77
Platelet activation, signaling and aggregationR-HSA-760025.15
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
GPCR ligand bindingR-HSA-5007924.19
GPCR downstream signalingR-HSA-3883963.07
Class A/1 (Rhodopsin-like receptors)R-HSA-3730764.69
Metabolism of proteinsR-HSA-3924993.41
Signaling by GPCRR-HSA-3727902.68
Thrombin signalling through proteinase activated receptors (PARs)R-HSA-4569267.98
G alpha (q) signalling eventsR-HSA-4164765.42
HemostasisR-HSA-1095823.98
Removal of aminoterminal propeptides from gamma-carboxylated proteinsR-HSA-1597829.81
Intrinsic Pathway of Fibrin Clot FormationR-HSA-1408378.52
Common Pathway of Fibrin Clot FormationR-HSA-1408758.52
Formation of Fibrin Clot (Clotting Cascade)R-HSA-1408777.7
Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusR-HSA-1597639.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
hydrolase activityGO:00167871.9
metal ion bindingGO:00468721.41
serine-type endopeptidase activityGO:00042524.4
growth factor activityGO:00080834.66
protein bindingGO:00055150.46
serine hydrolase activityGO:00171714.26
catalytic activityGO:00038241.05
cation bindingGO:00431691.4
thrombospondin receptor activityGO:00700538.35
ion bindingGO:00431671.36
molecular transducer activityGO:00600892.32
peptidase activity, acting on L-amino acid peptidesGO:00700113.26
bindingGO:00054880.18
signal transducer activityGO:00048712.28
receptor activityGO:00048722.32
signaling receptor activityGO:00380232.49
receptor bindingGO:00051022.43
serine-type peptidase activityGO:00082364.27
endopeptidase activityGO:00041753.63
peptidase activityGO:00082333.23
calcium ion bindingGO:00055093.17