| Disease ID | Disease name | Source of annotation with FADD | OMIM link | Number of associated genes | genes |
|---|---|---|---|---|---|
| 613759 | INFECTIONS, RECURRENT, WITH ENCEPHALOPATHY, HEPATIC DYSFUNCTION, AND CARDIOVASCULAR MALFORMATIONS | ClinVar, OMIM, HUMSAVAR | link to OMIM | 1 | FADD |
Download the gene annotation in CSV format
| KEGG pathway | KEGG ID | KEGG IC |
|---|---|---|
| Toll-like receptor signaling pathway | hsa04620 | 6.0 |
| Pathways in cancer | hsa05200 | 3.98 |
| RIG-I-like receptor signaling pathway | hsa04622 | 6.62 |
| Chagas disease (American trypanosomiasis) | hsa05142 | 5.99 |
| Herpes simplex infection | hsa05168 | 5.08 |
| Tuberculosis | hsa05152 | 5.17 |
| TNF signaling pathway | hsa04668 | 5.96 |
| Apoptosis | hsa04210 | 6.23 |
| Alzheimer's disease | hsa05010 | 5.34 |
| Hepatitis B | hsa05161 | 5.52 |
| REACTOME pathway | REACTOME ID | REACTOME IC |
|---|---|---|
| TRIF-mediated TLR3/TLR4 signaling | R-HSA-937061 | 6.47 |
| Immune System | R-HSA-168256 | 2.37 |
| Ligand-dependent caspase activation | R-HSA-140534 | 9.08 |
| Programmed Cell Death | R-HSA-5357801 | 5.65 |
| RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways | R-HSA-168928 | 6.7 |
| TRAIL signaling | R-HSA-75158 | 10.18 |
| TNFR1-induced proapoptotic signaling | R-HSA-5357786 | 9.28 |
| Toll Like Receptor 3 (TLR3) Cascade | R-HSA-168164 | 6.47 |
| Toll-Like Receptors Cascades | R-HSA-168898 | 5.91 |
| MyD88-independent TLR3/TLR4 cascade | R-HSA-166166 | 6.47 |
| Regulation by c-FLIP | R-HSA-3371378 | 9.81 |
| Dimerization of procaspase-8 | R-HSA-69416 | 9.81 |
| NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 | R-HSA-933543 | 9.4 |
| Toll Like Receptor 4 (TLR4) Cascade | R-HSA-166016 | 6.11 |
| RIPK1-mediated regulated necrosis | R-HSA-5213460 | 8.81 |
| Caspase activation via extrinsic apoptotic signalig pathway | R-HSA-5357769 | 8.34 |
| Innate Immune System | R-HSA-168249 | 3.17 |
| Regulated Necrosis | R-HSA-5218859 | 8.81 |
| Death Receptor Signalling | R-HSA-73887 | 8.52 |
| TRIF-mediated programmed cell death | R-HSA-2562578 | 9.66 |
| Regulation of necroptotic cell death | R-HSA-5675482 | 8.98 |
| TNF signaling | R-HSA-75893 | 9.08 |
| CASP8 activity is inhibited | R-HSA-5218900 | 9.81 |
| Apoptosis | R-HSA-109581 | 5.68 |
| FasL/ CD95L signaling | R-HSA-75157 | 10.66 |
| Activated TLR4 signalling | R-HSA-166054 | 6.27 |
| Signal Transduction | R-HSA-162582 | 1.78 |
| GO term | GO ID | GO IC |
|---|---|---|
| cytokine receptor binding | GO:0005126 | 4.14 |
| enzyme binding | GO:0019899 | 2.27 |
| tumor necrosis factor receptor superfamily binding | GO:0032813 | 5.89 |
| caspase binding | GO:0089720 | 8.35 |
| death receptor binding | GO:0005123 | 6.91 |
| death effector domain binding | GO:0035877 | 8.35 |
| tumor necrosis factor receptor binding | GO:0005164 | 6.3 |
| protease binding | GO:0002020 | 5.08 |
| macromolecular complex binding | GO:0044877 | 2.61 |
| binding | GO:0005488 | 0.18 |
| protein binding | GO:0005515 | 0.46 |
| protein complex binding | GO:0032403 | 3.09 |
| receptor binding | GO:0005102 | 2.43 |
| identical protein binding | GO:0042802 | 2.63 |
| protein domain specific binding | GO:0019904 | 3.32 |