Gene table of FGA : fibrinogen alpha chain

Gene-disease associations table

Disease IDDisease nameSource of annotation with FGAOMIM linkNumber of associated genesgenes
105200AMYLOIDOSIS, FAMILIAL VISCERALOMIM, HUMSAVAR link to OMIM 4APOA1, B2M, FGA, LYZ
202400AFIBRINOGENEMIA, CONGENITALOMIM, HUMSAVAR link to OMIM 3FGA, FGB, FGG
616004DYSFIBRINOGENEMIA, CONGENITALOMIM, HUMSAVAR link to OMIM 3FGA, FGB, FGG

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Annotation of the gene FGA

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Platelet activationhsa046115.66
Complement and coagulation cascadeshsa046106.58
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
NCAM signaling for neurite out-growthR-HSA-3751654.9
Platelet degranulation R-HSA-1146086.68
Signaling by InterleukinsR-HSA-4491474.71
Signaling by LeptinR-HSA-25865525.1
Frs2-mediated activationR-HSA-1709685.12
MAP2K and MAPK activationR-HSA-56741357.66
Cytokine Signaling in Immune systemR-HSA-12802153.74
Extracellular matrix organizationR-HSA-14742444.91
IGF1R signaling cascadeR-HSA-24289244.85
Downstream signal transductionR-HSA-1867634.65
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by ERBB4R-HSA-12363944.7
Innate Immune SystemR-HSA-1682493.17
IRS-mediated signallingR-HSA-1123994.87
MAPK1/MAPK3 signalingR-HSA-56849965.11
DiseaseR-HSA-16436853.33
RAF/MAP kinase cascadeR-HSA-56730015.15
Integrin cell surface interactionsR-HSA-2160836.57
Platelet Aggregation (Plug Formation)R-HSA-760097.77
Downstream signaling of activated FGFR1R-HSA-56546874.71
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Signaling by VEGFR-HSA-1941384.66
Signalling to p38 via RIT and RINR-HSA-1877065.12
Platelet activation, signaling and aggregationR-HSA-760025.15
FCERI mediated MAPK activationR-HSA-28717964.32
Response to elevated platelet cytosolic Ca2+R-HSA-760056.59
Signaling by EGFRR-HSA-1779294.59
p130Cas linkage to MAPK signaling for integrinsR-HSA-3727089.08
FRS-mediated FGFR2 signalingR-HSA-56547005.14
SOS-mediated signallingR-HSA-1124125.15
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Developmental BiologyR-HSA-12667383.48
AmyloidsR-HSA-9772257.37
Downstream signaling of activated FGFR3R-HSA-56547084.71
Insulin receptor signalling cascadeR-HSA-747514.85
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Interleukin receptor SHC signalingR-HSA-9125265.09
Signaling by FGFRR-HSA-1902364.67
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Immune SystemR-HSA-1682562.37
Downstream signaling of activated FGFR4R-HSA-56547164.71
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Signaling by SCF-KITR-HSA-14335574.73
Interleukin-2 signalingR-HSA-4519275.05
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Signaling by ERBB2R-HSA-12279864.66
Signalling to RASR-HSA-1670445.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Downstream signaling of activated FGFR2R-HSA-56546964.71
Signaling by FGFR1R-HSA-56547364.69
SHC1 events in EGFR signalingR-HSA-1803365.15
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Prolonged ERK activation eventsR-HSA-1698935.11
Formation of Fibrin Clot (Clotting Cascade)R-HSA-1408777.7
Signaling by GPCRR-HSA-3727902.68
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signalling to ERKsR-HSA-1876875.04
Signaling by Insulin receptorR-HSA-747524.73
Integrin alphaIIb beta3 signalingR-HSA-3541928.23
ARMS-mediated activationR-HSA-1709845.12
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-3541949.08
DAP12 interactionsR-HSA-21721274.56
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Common Pathway of Fibrin Clot FormationR-HSA-1408758.52
Axon guidanceR-HSA-4224753.93
VEGFR2 mediated cell proliferationR-HSA-52189215.07
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
cation bindingGO:00431691.4
protein binding, bridgingGO:00306744.68
metal ion bindingGO:00468721.41
structural molecule activityGO:00051983.1
ion bindingGO:00431671.36
bindingGO:00054880.18
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
cell adhesion molecule bindingGO:00508394.5
binding, bridgingGO:00600904.57