Gene table of FGF23 : fibroblast growth factor 23

Gene-disease associations table

Disease IDDisease nameSource of annotation with FGF23OMIM linkNumber of associated genesgenes
PS193100HYPOPHOSPHATEMIC RICKETSClinVar, OMIM, HUMSAVAR link to OMIM 5FGF23, DMP1, ENPP1, CLCN5, PHEX
211900TUMORAL CALCINOSIS, HYPERPHOSPHATEMIC, FAMILIALClinVar, OMIM, HUMSAVAR link to OMIM 3FGF23, KL, GALNT3

Download the gene annotation in CSV format

Annotation of the gene FGF23

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Melanomahsa052186.56
Pathways in cancerhsa052003.98
Rap1 signaling pathwayhsa040154.97
Ras signaling pathwayhsa040144.9
MAPK signaling pathwayhsa040104.63
Regulation of actin cytoskeletonhsa048104.9
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Signaling by FGFR1 in diseaseR-HSA-56553027.81
Signaling by EGFRR-HSA-1779294.59
FGFR4 ligand binding and activationR-HSA-1903229.18
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Phospholipase C-mediated cascade; FGFR2R-HSA-56542217.37
PI3K/AKT activationR-HSA-1982036.32
Phospholipase C-mediated cascade; FGFR3R-HSA-56542277.52
Phospholipase C-mediated cascade; FGFR4R-HSA-56542287.46
Immune SystemR-HSA-1682562.37
Frs2-mediated activationR-HSA-1709685.12
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
SHC-mediated cascade:FGFR3R-HSA-56547048.81
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by activated point mutants of FGFR1R-HSA-18391229.52
FGFR1 mutant receptor activationR-HSA-18391248.12
Signaling by FGFR in diseaseR-HSA-12260997.49
FGFR2 mutant receptor activationR-HSA-18391268.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
SHC-mediated cascade:FGFR4R-HSA-56547198.46
Downstream signaling of activated FGFR1R-HSA-56546874.71
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
Negative regulation of FGFR4 signalingR-HSA-56547338.03
Negative regulation of FGFR3 signalingR-HSA-56547328.12
PI3K CascadeR-HSA-1097046.68
Axon guidanceR-HSA-4224753.93
Signaling by FGFR2 in diseaseR-HSA-56552538.23
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Signaling by FGFR3 in diseaseR-HSA-56553328.52
FGFR1 ligand binding and activationR-HSA-1902428.98
FGFR2 ligand binding and activationR-HSA-1902418.66
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
FGFR1c and Klotho ligand binding and activationR-HSA-19037411.4
FGFR2c ligand binding and activationR-HSA-1903759.28
FGFR3c ligand binding and activationR-HSA-1903729.4
FGFR1c ligand binding and activationR-HSA-1903739.4
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
SHC-mediated cascade:FGFR1R-HSA-56546888.59
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Negative regulation of FGFR2 signalingR-HSA-56547277.89
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Signalling to RASR-HSA-1670445.08
SHC-mediated cascade:FGFR2R-HSA-56546998.28
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
PI3K events in ERBB4 signalingR-HSA-12503426.37
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
Phospholipase C-mediated cascade: FGFR1R-HSA-56542197.43
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Activated point mutants of FGFR2R-HSA-20335198.89
Signaling by FGFRR-HSA-1902364.67
FGFR3 mutant receptor activationR-HSA-20335149.4
FGFR3 ligand binding and activationR-HSA-1902399.4
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Signaling by activated point mutants of FGFR3R-HSA-18391309.4
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
guanyl-nucleotide exchange factor activityGO:00050854.02
bindingGO:00054880.18
phosphatidylinositol 3-kinase activityGO:00350045.49
molecular function regulatorGO:00987722.51
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
growth factor activityGO:00080834.66
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
protein tyrosine kinase activityGO:00047134.54
protein kinase activityGO:00046723.27
1-phosphatidylinositol-3-kinase activityGO:00163035.98
kinase activityGO:00163012.93
catalytic activityGO:00038241.05
growth factor receptor bindingGO:00708514.87
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
phosphatidylinositol kinase activityGO:00527425.81
protein bindingGO:00055150.46
receptor bindingGO:00051022.43
fibroblast growth factor receptor bindingGO:00051046.41
type 1 fibroblast growth factor receptor bindingGO:00051058.13