Gene table of FGF3 : fibroblast growth factor 3

Gene-disease associations table

Disease IDDisease nameSource of annotation with FGF3OMIM linkNumber of associated genesgenes
610706DEAFNESS, CONGENITAL, WITH INNER EAR AGENESIS, MICROTIA, AND MICRODONTIAClinVar, OMIM, HUMSAVAR link to OMIM 1FGF3

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Annotation of the gene FGF3

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Melanomahsa052186.56
Pathways in cancerhsa052003.98
Rap1 signaling pathwayhsa040154.97
Ras signaling pathwayhsa040144.9
MAPK signaling pathwayhsa040104.63
Regulation of actin cytoskeletonhsa048104.9
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Signaling by EGFRR-HSA-1779294.59
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Phospholipase C-mediated cascade; FGFR2R-HSA-56542217.37
PI3K/AKT activationR-HSA-1982036.32
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Frs2-mediated activationR-HSA-1709685.12
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by FGFR in diseaseR-HSA-12260997.49
FGFR2 mutant receptor activationR-HSA-18391268.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
PI3K events in ERBB4 signalingR-HSA-12503426.37
PI3K CascadeR-HSA-1097046.68
Axon guidanceR-HSA-4224753.93
Signaling by FGFR2 in diseaseR-HSA-56552538.23
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
FGFR1 ligand binding and activationR-HSA-1902428.98
FGFR2 ligand binding and activationR-HSA-1902418.66
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
FGFR2b ligand binding and activationR-HSA-1903779.66
Downstream signaling of activated FGFR1R-HSA-56546874.71
FGFR1b ligand binding and activationR-HSA-19037010.4
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
SHC-mediated cascade:FGFR1R-HSA-56546888.59
Negative regulation of FGFR1 signalingR-HSA-56547267.98
Negative regulation of FGFR2 signalingR-HSA-56547277.89
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Immune SystemR-HSA-1682562.37
Signalling to RASR-HSA-1670445.08
SHC-mediated cascade:FGFR2R-HSA-56546998.28
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
Phospholipase C-mediated cascade: FGFR1R-HSA-56542197.43
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Activated point mutants of FGFR2R-HSA-20335198.89
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
growth factor receptor bindingGO:00708514.87
phosphatidylinositol 3-kinase activityGO:00350045.49
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
phosphatidylinositol kinase activityGO:00527425.81
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
catalytic activityGO:00038241.05
kinase activityGO:00163012.93
guanyl-nucleotide exchange factor activityGO:00050854.02
growth factor activityGO:00080834.66
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
transferase activityGO:00167401.95
bindingGO:00054880.18
protein bindingGO:00055150.46
protein kinase activityGO:00046723.27
1-phosphatidylinositol-3-kinase activityGO:00163035.98
molecular function regulatorGO:00987722.51
fibroblast growth factor receptor bindingGO:00051046.41
receptor bindingGO:00051022.43
protein tyrosine kinase activityGO:00047134.54