Gene table of FGFR2 : fibroblast growth factor receptor 2

Gene-disease associations table

Disease IDDisease nameSource of annotation with FGFR2OMIM linkNumber of associated genesgenes
609579SCAPHOCEPHALY, MAXILLARY RETRUSION, AND MENTAL RETARDATIONOMIM, HUMSAVAR link to OMIM 1FGFR2
101600PFEIFFER SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 2FGFR1, FGFR2
123500CROUZON SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 1FGFR2
101200APERT SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 1FGFR2
149730LACRIMOAURICULODENTODIGITAL SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 3FGFR3, FGFR2, FGF10
123790BEARE-STEVENSON CUTIS GYRATA SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 1FGFR2
123150JACKSON-WEISS SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 2FGFR1, FGFR2
207410ANTLEY-BIXLER SYNDROME WITHOUT GENITAL ANOMALIES OR DISORDERED STEROIDOGENESISClinVar, OMIM, HUMSAVAR link to OMIM 1FGFR2
613659GASTRIC CANCEROMIM link to OMIM 9KLF6, ERBB2, PIK3CA, APC, CASP10, IRF1, FGFR2, MUTYH, KRAS
614592BENT BONE DYSPLASIA SYNDROMEClinVar, OMIM, HUMSAVAR link to OMIM 1FGFR2
101400SAETHRE-CHOTZEN SYNDROMEOMIM link to OMIM 3FGFR3, TWIST1, FGFR2

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Annotation of the gene FGFR2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Signaling pathways regulating pluripotency of stem cellshsa045505.6
Pathways in cancerhsa052003.98
Prostate cancerhsa052156.11
Rap1 signaling pathwayhsa040154.97
Ras signaling pathwayhsa040144.9
Central carbon metabolism in cancerhsa052306.7
Endocytosishsa041444.92
MAPK signaling pathwayhsa040104.63
Regulation of actin cytoskeletonhsa048104.9
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Signaling by EGFRR-HSA-1779294.59
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
Phospholipase C-mediated cascade; FGFR2R-HSA-56542217.37
PI3K/AKT activationR-HSA-1982036.32
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Frs2-mediated activationR-HSA-1709685.12
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Signalling to p38 via RIT and RINR-HSA-1877065.12
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by FGFR in diseaseR-HSA-12260997.49
FGFR2 mutant receptor activationR-HSA-18391268.89
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
PI3K events in ERBB4 signalingR-HSA-12503426.37
PI3K CascadeR-HSA-1097046.68
Axon guidanceR-HSA-4224753.93
Signaling by FGFR2 in diseaseR-HSA-56552538.23
FGFR2 ligand binding and activationR-HSA-1902418.66
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
FGFR2b ligand binding and activationR-HSA-1903779.66
FGFR2c ligand binding and activationR-HSA-1903759.28
Downstream signaling of activated FGFR1R-HSA-56546874.71
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Negative regulation of FGFR2 signalingR-HSA-56547277.89
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Immune SystemR-HSA-1682562.37
Signalling to RASR-HSA-1670445.08
SHC-mediated cascade:FGFR2R-HSA-56546998.28
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
ARMS-mediated activationR-HSA-1709845.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by FGFR2 amplification mutantsR-HSA-202383712.98
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Activated point mutants of FGFR2R-HSA-20335198.89
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
signaling receptor activityGO:00380232.49
signal transducer activityGO:00048712.28
purine ribonucleoside triphosphate bindingGO:00356392.22
guanyl-nucleotide exchange factor activityGO:00050854.02
heterocyclic compound bindingGO:19013631.06
molecular transducer activityGO:00600892.32
bindingGO:00054880.18
phosphatidylinositol 3-kinase activityGO:00350045.49
molecular function regulatorGO:00987722.51
transmembrane receptor activityGO:00996002.53
nucleoside phosphate bindingGO:19012651.96
nucleoside bindingGO:00018822.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
transmembrane receptor protein tyrosine kinase activityGO:00047145.55
protein tyrosine kinase activityGO:00047134.54
growth factor bindingGO:00198384.89
nucleotide bindingGO:00001661.96
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transferase activityGO:00167401.95
purine nucleoside bindingGO:00018832.22
protein kinase activityGO:00046723.27
purine nucleotide bindingGO:00170762.19
ATP bindingGO:00055242.43
protein homodimerization activityGO:00428033.16
sulfur compound bindingGO:19016814.32
kinase activityGO:00163012.93
protein bindingGO:00055150.46
1-phosphatidylinositol-3-kinase activityGO:00163035.98
ribonucleoside bindingGO:00325492.22
fibroblast growth factor bindingGO:00171346.52
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
heparin bindingGO:00082014.68
adenyl nucleotide bindingGO:00305542.4
phosphatidylinositol kinase activityGO:00527425.81
organic cyclic compound bindingGO:00971591.05
glycosaminoglycan bindingGO:00055394.42
carbohydrate derivative bindingGO:00973672.03
transmembrane signaling receptor activityGO:00048882.57
adenyl ribonucleotide bindingGO:00325592.41
identical protein bindingGO:00428022.63
fibroblast growth factor-activated receptor activityGO:00050078.13
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
protein dimerization activityGO:00469832.72
transmembrane receptor protein kinase activityGO:00191995.32
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19
receptor activityGO:00048722.32