Gene table of FGFR4 : fibroblast growth factor receptor 4

Gene-disease associations table

Disease IDDisease nameSource of annotation with FGFR4OMIM linkNumber of associated genesgenes
176807PROSTATE CANCERHUMSAVAR link to OMIM 15PTEN, EPHB2, KLF6, AR, HIP1, CD82, ZFHX3, BRCA2, CDH1, CHEK2, MXI1, MAD1L1, HOXB13, MSR1, FGFR4

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Annotation of the gene FGFR4

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Signaling pathways regulating pluripotency of stem cellshsa045505.6
Rap1 signaling pathwayhsa040154.97
Ras signaling pathwayhsa040144.9
Endocytosishsa041444.92
MAPK signaling pathwayhsa040104.63
Regulation of actin cytoskeletonhsa048104.9
PI3K-Akt signaling pathwayhsa041514.21
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Interleukin-2 signalingR-HSA-4519275.05
Signaling by the B Cell Receptor (BCR)R-HSA-9837054.62
GAB1 signalosomeR-HSA-1802926.31
Developmental BiologyR-HSA-12667383.48
Signaling by VEGFR-HSA-1941384.66
FCERI mediated MAPK activationR-HSA-28717964.32
IRS-mediated signallingR-HSA-1123994.87
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
Signaling by EGFRR-HSA-1779294.59
FGFR4 ligand binding and activationR-HSA-1903229.18
PI-3K cascade:FGFR3R-HSA-56547106.37
DAP12 interactionsR-HSA-21721274.56
Downstream signaling of activated FGFR4R-HSA-56547164.71
Signaling by ERBB2R-HSA-12279864.66
VEGFR2 mediated cell proliferationR-HSA-52189215.07
PI3K/AKT activationR-HSA-1982036.32
Phospholipase C-mediated cascade; FGFR4R-HSA-56542287.46
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Frs2-mediated activationR-HSA-1709685.12
PI3K events in ERBB2 signalingR-HSA-19636426.37
Downstream signal transductionR-HSA-1867634.65
Role of LAT2/NTAL/LAB on calcium mobilizationR-HSA-27309054.95
Signalling to p38 via RIT and RINR-HSA-1877065.12
FGFR4 mutant receptor activationR-HSA-183912812.98
FRS-mediated FGFR2 signalingR-HSA-56547005.14
FRS-mediated FGFR4 signalingR-HSA-56547125.14
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Downstream signaling of activated FGFR3R-HSA-56547084.71
Signaling by FGFR in diseaseR-HSA-12260997.49
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Interleukin receptor SHC signalingR-HSA-9125265.09
Innate Immune SystemR-HSA-1682493.17
SHC-mediated cascade:FGFR4R-HSA-56547198.46
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
Prolonged ERK activation eventsR-HSA-1698935.11
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signaling by FGFR1R-HSA-56547364.69
PI3K events in ERBB4 signalingR-HSA-12503426.37
PI3K CascadeR-HSA-1097046.68
Axon guidanceR-HSA-4224753.93
Signaling by LeptinR-HSA-25865525.1
Constitutive Signaling by Aberrant PI3K in CancerR-HSA-22195307.05
IGF1R signaling cascadeR-HSA-24289244.85
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by Insulin receptorR-HSA-747524.73
DiseaseR-HSA-16436853.33
Insulin receptor signalling cascadeR-HSA-747514.85
Downstream signaling of activated FGFR1R-HSA-56546874.71
PI-3K cascade:FGFR4R-HSA-56547206.37
PI-3K cascade:FGFR1R-HSA-56546896.37
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Downstream signaling events of B Cell Receptor (BCR)R-HSA-11683725.59
PI3K/AKT Signaling in CancerR-HSA-22195286.56
Diseases of signal transductionR-HSA-56632024.89
Immune SystemR-HSA-1682562.37
Signalling to RASR-HSA-1670445.08
PI-3K cascade:FGFR2R-HSA-56546956.37
Downstream signaling of activated FGFR2R-HSA-56546964.71
SHC1 events in EGFR signalingR-HSA-1803365.15
FRS-mediated FGFR1 signalingR-HSA-56546935.14
SHC1 events in ERBB2 signalingR-HSA-12501965.15
betaKlotho-mediated ligand bindingR-HSA-130796511.4
ARMS-mediated activationR-HSA-1709845.12
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Signaling by InterleukinsR-HSA-4491474.71
Negative regulation of FGFR4 signalingR-HSA-56547338.03
Cytokine Signaling in Immune systemR-HSA-12802153.74
SOS-mediated signallingR-HSA-1124125.15
Signaling by ERBB4R-HSA-12363944.7
MAPK1/MAPK3 signalingR-HSA-56849965.11
Adaptive Immune SystemR-HSA-12802183.19
MAPK family signaling cascadesR-HSA-56830574.89
PIP3 activates AKT signalingR-HSA-12576046.37
RAF/MAP kinase cascadeR-HSA-56730015.15
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
Signaling by FGFRR-HSA-1902364.67
Signaling by SCF-KITR-HSA-14335574.73
NCAM signaling for neurite out-growthR-HSA-3751654.9
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Signalling by NGFR-HSA-1665204.23
Signaling by GPCRR-HSA-3727902.68
Signalling to ERKsR-HSA-1876875.04
Signaling by FGFR4 in diseaseR-HSA-56552919.52
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
Ras guanyl-nucleotide exchange factor activityGO:00050884.31
signaling receptor activityGO:00380232.49
signal transducer activityGO:00048712.28
purine ribonucleoside triphosphate bindingGO:00356392.22
guanyl-nucleotide exchange factor activityGO:00050854.02
growth factor bindingGO:00198384.89
molecular transducer activityGO:00600892.32
bindingGO:00054880.18
phosphatidylinositol 3-kinase activityGO:00350045.49
molecular function regulatorGO:00987722.51
heterocyclic compound bindingGO:19013631.06
purine nucleoside bindingGO:00018832.22
nucleoside bindingGO:00018822.21
phosphatidylinositol-4,5-bisphosphate 3-kinase activityGO:00469345.61
transferase activityGO:00167401.95
nucleotide bindingGO:00001661.96
phosphatidylinositol bisphosphate kinase activityGO:00528135.56
transmembrane receptor protein tyrosine kinase activityGO:00047145.55
protein tyrosine kinase activityGO:00047134.54
ribonucleoside bindingGO:00325492.22
purine nucleotide bindingGO:00170762.19
protein kinase activityGO:00046723.27
ATP bindingGO:00055242.43
sulfur compound bindingGO:19016814.32
protein bindingGO:00055150.46
1-phosphatidylinositol-3-kinase activityGO:00163035.98
kinase activityGO:00163012.93
nucleoside phosphate bindingGO:19012651.96
small molecule bindingGO:00360941.89
catalytic activityGO:00038241.05
fibroblast growth factor bindingGO:00171346.52
phosphotransferase activity, alcohol group as acceptorGO:00167733.08
heparin bindingGO:00082014.68
adenyl nucleotide bindingGO:00305542.4
carbohydrate derivative bindingGO:00973672.03
organic cyclic compound bindingGO:00971591.05
glycosaminoglycan bindingGO:00055394.42
phosphatidylinositol kinase activityGO:00527425.81
transmembrane signaling receptor activityGO:00048882.57
adenyl ribonucleotide bindingGO:00325592.41
transmembrane receptor activityGO:00996002.53
fibroblast growth factor-activated receptor activityGO:00050078.13
transferase activity, transferring phosphorus-containing groupsGO:00167722.77
purine ribonucleotide bindingGO:00325552.2
transmembrane receptor protein kinase activityGO:00191995.32
purine ribonucleoside bindingGO:00325502.22
ribonucleotide bindingGO:00325532.19
receptor activityGO:00048722.32