Gene table of FLT3 : fms related tyrosine kinase 3

Gene-disease associations table

Disease ID	Disease name	Source of annotation with FLT3	OMIM link	Number of associated genes	genes
601626	LEUKEMIA, ACUTE MYELOID	ClinVar, OMIM	link to OMIM	23	FLT3, RUNX1, WHSC1L1, KIT, MLF1, CHIC2, CEBPA, LPP, SH3GL1, PICALM, NPM1, CBFB, ETV6, SETBP1, MLLT10, TERT, NUP214, JAK2, GATA2, TGM6, DDX41, NSD1, KRAS
613065	LEUKEMIA, ACUTE LYMPHOBLASTIC	ClinVar, OMIM	link to OMIM	9	PAX5, BCR, BAX, FLT3, NBN, TAL2, TAL1, NUP214, TCF3

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Annotation of the gene FLT3

Associated genes in ENSEMBL

ENSG00000122025

Associated proteins - SwissProt Accession ID

P36888

Associated PDB IDs

Cytogenetic Band

13q12.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Hematopoietic cell lineage	hsa04640	6.18
Pathways in cancer	hsa05200	3.98
Transcriptional misregulation in cancer	hsa05202	5.21
Central carbon metabolism in cancer	hsa05230	6.7
Acute myeloid leukemia	hsa05221	6.74
Cytokine-cytokine receptor interaction	hsa04060	4.67

Associated REACTOME pathways

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
molecular transducer activity	GO:0060089	2.32
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
heterocyclic compound binding	GO:1901363	1.06
purine nucleoside binding	GO:0001883	2.22
nucleoside binding	GO:0001882	2.21
cytokine receptor activity	GO:0004896	5.24
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
identical protein binding	GO:0042802	2.63
protein tyrosine kinase activity	GO:0004713	4.54
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
protein kinase activity	GO:0004672	3.27
ATP binding	GO:0005524	2.43
protein homodimerization activity	GO:0042803	3.16
glucocorticoid receptor binding	GO:0035259	6.97
steroid hormone receptor binding	GO:0035258	5.32
kinase activity	GO:0016301	2.93
nuclear hormone receptor binding	GO:0035257	4.7
nucleoside phosphate binding	GO:1901265	1.96
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
hormone receptor binding	GO:0051427	4.57
protein dimerization activity	GO:0046983	2.72
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
vascular endothelial growth factor-activated receptor activity	GO:0005021	7.79
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32