Gene table of FLT4 : fms related tyrosine kinase 4

Gene-disease associations table

Disease ID	Disease name	Source of annotation with FLT4	OMIM link	Number of associated genes	genes
602089	HEMANGIOMA, CAPILLARY INFANTILE	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	FLT4, ANTXR1, KDR
PS153100	LYMPHEDEMA, HEREDITARY	ClinVar, OMIM, HUMSAVAR	link to OMIM	3	FLT4, VEGFC, GJC2

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Annotation of the gene FLT4

Associated genes in ENSEMBL

ENSG00000037280

Associated proteins - SwissProt Accession ID

P35916

Associated PDB IDs

Cytogenetic Band

5q35.3

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Rap1 signaling pathway	hsa04015	4.97
Ras signaling pathway	hsa04014	4.9
Focal adhesion	hsa04510	4.92
Cytokine-cytokine receptor interaction	hsa04060	4.67
PI3K-Akt signaling pathway	hsa04151	4.21

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by VEGF	R-HSA-194138	4.66
VEGF binds to VEGFR leading to receptor dimerization	R-HSA-195399	9.98
VEGF ligand-receptor interactions	R-HSA-194313	9.98
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
signaling receptor activity	GO:0038023	2.49
purine ribonucleoside triphosphate binding	GO:0035639	2.22
enzyme binding	GO:0019899	2.27
growth factor binding	GO:0019838	4.89
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
purine nucleoside binding	GO:0001883	2.22
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
transferase activity	GO:0016740	1.95
nucleotide binding	GO:0000166	1.96
transmembrane receptor protein tyrosine kinase activity	GO:0004714	5.55
protein tyrosine kinase activity	GO:0004713	4.54
protein kinase activity	GO:0004672	3.27
purine nucleotide binding	GO:0017076	2.19
ATP binding	GO:0005524	2.43
kinase activity	GO:0016301	2.93
ribonucleoside binding	GO:0032549	2.22
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
adenyl nucleotide binding	GO:0030554	2.4
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
vascular endothelial growth factor-activated receptor activity	GO:0005021	7.79
phosphotransferase activity, alcohol group as acceptor	GO:0016773	3.08
transmembrane signaling receptor activity	GO:0004888	2.57
adenyl ribonucleotide binding	GO:0032559	2.41
transmembrane receptor activity	GO:0099600	2.53
protein binding	GO:0005515	0.46
transferase activity, transferring phosphorus-containing groups	GO:0016772	2.77
purine ribonucleotide binding	GO:0032555	2.2
transmembrane receptor protein kinase activity	GO:0019199	5.32
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32