Gene table of FN1 : fibronectin 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with FN1OMIM linkNumber of associated genesgenes
614101PLASMA FIBRONECTIN DEFICIENCYOMIM link to OMIM 1FN1
PS137950GLOMERULOPATHY WITH FIBRONECTIN DEPOSITSClinVar, OMIM, HUMSAVAR link to OMIM 1FN1

Download the gene annotation in CSV format

Annotation of the gene FN1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Bacterial invasion of epithelial cellshsa051006.34
Proteoglycans in cancerhsa052055.02
Pathways in cancerhsa052003.98
Amoebiasishsa051465.82
Small cell lung cancerhsa052226.17
Focal adhesionhsa045104.92
ECM-receptor interactionhsa045126.09
PI3K-Akt signaling pathwayhsa041514.21
Regulation of actin cytoskeletonhsa048104.9
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)R-HSA-24041924.85
Gastrin-CREB signalling pathway via PKC and MAPKR-HSA-8819074.26
Molecules associated with elastic fibresR-HSA-21293797.73
Platelet degranulation R-HSA-1146086.68
Signaling by InterleukinsR-HSA-4491474.71
Signaling by LeptinR-HSA-25865525.1
Frs2-mediated activationR-HSA-1709685.12
MAP2K and MAPK activationR-HSA-56741357.66
Degradation of the extracellular matrixR-HSA-14742286.11
Cytokine Signaling in Immune systemR-HSA-12802153.74
Extracellular matrix organizationR-HSA-14742444.91
IGF1R signaling cascadeR-HSA-24289244.85
Downstream signal transductionR-HSA-1867634.65
NCAM signaling for neurite out-growthR-HSA-3751654.9
IRS-related events triggered by IGF1RR-HSA-24289284.85
Signaling by ERBB4R-HSA-12363944.7
IRS-mediated signallingR-HSA-1123994.87
MAPK1/MAPK3 signalingR-HSA-56849965.11
Developmental BiologyR-HSA-12667383.48
RAF/MAP kinase cascadeR-HSA-56730015.15
Integrin cell surface interactionsR-HSA-2160836.57
Platelet Aggregation (Plug Formation)R-HSA-760097.77
Downstream signaling of activated FGFR1R-HSA-56546874.71
MAPK family signaling cascadesR-HSA-56830574.89
Signalling by NGFR-HSA-1665204.23
Elastic fibre formationR-HSA-15669487.49
GRB2:SOS provides linkage to MAPK signaling for Integrins R-HSA-3541949.08
Platelet activation, signaling and aggregationR-HSA-760025.15
FCERI mediated MAPK activationR-HSA-28717964.32
Integrin alphaIIb beta3 signalingR-HSA-3541928.23
Signaling by EGFRR-HSA-1779294.59
ECM proteoglycansR-HSA-30001786.75
p130Cas linkage to MAPK signaling for integrinsR-HSA-3727089.08
FRS-mediated FGFR2 signalingR-HSA-56547005.14
DAP12 interactionsR-HSA-21721274.56
FRS-mediated FGFR3 signalingR-HSA-56547065.14
Signaling by Insulin receptorR-HSA-747524.73
Syndecan interactionsR-HSA-30001708.23
Non-integrin membrane-ECM interactionsR-HSA-30001717.1
Downstream signaling of activated FGFR3R-HSA-56547084.71
Insulin receptor signalling cascadeR-HSA-747514.85
Signaling by FGFR4R-HSA-56547434.69
Signaling by FGFR3R-HSA-56547414.69
VEGFA-VEGFR2 PathwayR-HSA-44200974.7
GRB2 events in ERBB2 signalingR-HSA-19636405.15
Interleukin receptor SHC signalingR-HSA-9125265.09
Signaling by FGFRR-HSA-1902364.67
Fc epsilon receptor (FCERI) signalingR-HSA-24542024.03
Immune SystemR-HSA-1682562.37
Downstream signaling of activated FGFR4R-HSA-56547164.71
Innate Immune SystemR-HSA-1682493.17
Signalling to p38 via RIT and RINR-HSA-1877065.12
Interleukin-2 signalingR-HSA-4519275.05
SHC1 events in ERBB2 signalingR-HSA-12501965.15
Signaling by ERBB2R-HSA-12279864.66
Signalling to RASR-HSA-1670445.08
DAP12 signalingR-HSA-24244914.64
Interleukin-3, 5 and GM-CSF signalingR-HSA-5129884.99
Downstream signaling of activated FGFR2R-HSA-56546964.71
Signaling by FGFR1R-HSA-56547364.69
SHC1 events in EGFR signalingR-HSA-1803365.15
NGF signalling via TRKA from the plasma membraneR-HSA-1870374.51
FRS-mediated FGFR1 signalingR-HSA-56546935.14
Prolonged ERK activation eventsR-HSA-1698935.11
FRS-mediated FGFR4 signalingR-HSA-56547125.14
Cell surface interactions at the vascular wallR-HSA-2027336.32
Signaling by GPCRR-HSA-3727902.68
Signaling by FGFR2R-HSA-56547384.68
GRB2 events in EGFR signalingR-HSA-1798125.15
Signalling to ERKsR-HSA-1876875.04
Fibronectin matrix formationR-HSA-156697710.4
ARMS-mediated activationR-HSA-1709845.12
Signaling by VEGFR-HSA-1941384.66
Signaling by SCF-KITR-HSA-14335574.73
SOS-mediated signallingR-HSA-1124125.15
SHC1 events in ERBB4 signalingR-HSA-12503475.15
Signaling by PDGFR-HSA-1867974.53
Response to elevated platelet cytosolic Ca2+R-HSA-760056.59
Axon guidanceR-HSA-4224753.93
VEGFR2 mediated cell proliferationR-HSA-52189215.07
HemostasisR-HSA-1095823.98
Signal TransductionR-HSA-1625821.78
Associated GO terms for Molecular function
GO termGO IDGO IC
enzyme bindingGO:00198992.27
macromolecular complex bindingGO:00448772.61
enzyme activator activityGO:00080473.56
molecular function regulatorGO:00987722.51
sulfur compound bindingGO:19016814.32
cation bindingGO:00431691.4
mercury ion bindingGO:00453409.05
transition metal ion bindingGO:00469142.48
ion bindingGO:00431671.36
protease bindingGO:00020205.08
protein complex bindingGO:00324033.09
metal ion bindingGO:00468721.41
identical protein bindingGO:00428022.63
integrin bindingGO:00051785.07
enzyme regulator activityGO:00302342.85
peptidase regulator activityGO:00611344.37
cell adhesion molecule bindingGO:00508394.5
heparin bindingGO:00082014.68
carbohydrate derivative bindingGO:00973672.03
glycosaminoglycan bindingGO:00055394.42
protein bindingGO:00055150.46
peptidase activator activityGO:00165046.13
receptor bindingGO:00051022.43
collagen bindingGO:00055185.58
bindingGO:00054880.18