Gene table of FOXO1 : forkhead box O1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with FOXO1	OMIM link	Number of associated genes	genes
268220	RHABDOMYOSARCOMA 2	OMIM	link to OMIM	3	FOXO1, PAX7, PAX3

Download the gene annotation in CSV format

Annotation of the gene FOXO1

Associated genes in ENSEMBL

ENSG00000150907

Associated proteins - SwissProt Accession ID

Q12778

Associated PDB IDs

Cytogenetic Band

13q14.11

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Prostate cancer	hsa05215	6.11
Pathways in cancer	hsa05200	3.98
Transcriptional misregulation in cancer	hsa05202	5.21
Insulin signaling pathway	hsa04910	5.55
FoxO signaling pathway	hsa04068	5.63
Thyroid hormone signaling pathway	hsa04919	5.82
AMPK signaling pathway	hsa04152	5.8

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Regulation of gene expression in beta cells	R-HSA-210745	8.66
PI3K/AKT activation	R-HSA-198203	6.32
Immune System	R-HSA-168256	2.37
Signaling by the B Cell Receptor (BCR)	R-HSA-983705	4.62
Downstream signal transduction	R-HSA-186763	4.65
GAB1 signalosome	R-HSA-180292	6.31
Signaling by ERBB4	R-HSA-1236394	4.7
Adaptive Immune System	R-HSA-1280218	3.19
Developmental Biology	R-HSA-1266738	3.48
Role of LAT2/NTAL/LAB on calcium mobilization	R-HSA-2730905	4.95
PI3K events in ERBB2 signaling	R-HSA-1963642	6.37
Downstream signaling of activated FGFR1	R-HSA-5654687	4.71
MAPK family signaling cascades	R-HSA-5683057	4.89
PIP3 activates AKT signaling	R-HSA-1257604	6.37
Signalling by NGF	R-HSA-166520	4.23
PI-3K cascade:FGFR4	R-HSA-5654720	6.37
PI-3K cascade:FGFR1	R-HSA-5654689	6.37
Constitutive Signaling by AKT1 E17K in Cancer	R-HSA-5674400	8.4
Disease	R-HSA-1643685	3.33
AKT-mediated inactivation of FOXO1A	R-HSA-211163	10.98
Downstream signaling events of B Cell Receptor (BCR)	R-HSA-1168372	5.59
Downstream signaling of activated FGFR3	R-HSA-5654708	4.71
Signaling by FGFR4	R-HSA-5654743	4.69
Signaling by FGFR3	R-HSA-5654741	4.69
Signaling by FGFR	R-HSA-190236	4.67
PI3K/AKT Signaling in Cancer	R-HSA-2219528	6.56
Diseases of signal transduction	R-HSA-5663202	4.89
Fc epsilon receptor (FCERI) signaling	R-HSA-2454202	4.03
MAPK6/MAPK4 signaling	R-HSA-5687128	6.54
Innate Immune System	R-HSA-168249	3.17
Signaling by SCF-KIT	R-HSA-1433557	4.73
AKT phosphorylates targets in the nucleus	R-HSA-198693	9.81
Signaling by PDGF	R-HSA-186797	4.53
DAP12 signaling	R-HSA-2424491	4.64
PI-3K cascade:FGFR2	R-HSA-5654695	6.37
Downstream signaling of activated FGFR2	R-HSA-5654696	4.71
Signaling by EGFR	R-HSA-177929	4.59
NGF signalling via TRKA from the plasma membrane	R-HSA-187037	4.51
Regulation of beta-cell development	R-HSA-186712	7.98
Signaling by FGFR2	R-HSA-5654738	4.68
Signaling by FGFR1	R-HSA-5654736	4.69
PI3K events in ERBB4 signaling	R-HSA-1250342	6.37
PI-3K cascade:FGFR3	R-HSA-5654710	6.37
DAP12 interactions	R-HSA-2172127	4.56
Downstream signaling of activated FGFR4	R-HSA-5654716	4.71
Signaling by ERBB2	R-HSA-1227986	4.66
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
ubiquitin-like protein ligase binding	GO:0044389	4.15
enzyme binding	GO:0019899	2.27
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001078	5.08
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
transcription factor binding	GO:0008134	3.46
beta-catenin binding	GO:0008013	5.3
protein phosphatase binding	GO:0019903	4.93
phosphatase binding	GO:0019902	4.63
protein phosphatase 2A binding	GO:0051721	6.41
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001227	4.61
ubiquitin protein ligase binding	GO:0031625	4.17
transcription cofactor binding	GO:0001221	6.52
transcription coactivator binding	GO:0001223	7.34
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
protein binding	GO:0005515	0.46
chromatin binding	GO:0003682	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65