Disease ID | Disease name | Source of annotation with FZD4 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS133780 | EXUDATIVE VITREORETINOPATHY | ClinVar, OMIM, HUMSAVAR | link to OMIM | 6 | NDP, TSPAN12, ZNF408, PRSS23, FZD4, LRP5 |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
Signaling pathways regulating pluripotency of stem cells | hsa04550 | 5.6 |
Proteoglycans in cancer | hsa05205 | 5.02 |
Pathways in cancer | hsa05200 | 3.98 |
Basal cell carcinoma | hsa05217 | 6.79 |
Melanogenesis | hsa04916 | 5.97 |
Hippo signaling pathway | hsa04390 | 5.37 |
HTLV-I infection | hsa05166 | 4.59 |
Wnt signaling pathway | hsa04310 | 5.49 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Class B/2 (Secretin family receptors) | R-HSA-373080 | 6.52 |
Signaling by Wnt | R-HSA-195721 | 4.79 |
Asymmetric localization of PCP proteins | R-HSA-4608870 | 7.01 |
Signaling by GPCR | R-HSA-372790 | 2.68 |
RNF mutants show enhanced WNT signaling and proliferation | R-HSA-5340588 | 9.98 |
Diseases of signal transduction | R-HSA-5663202 | 4.89 |
beta-catenin independent WNT signaling | R-HSA-3858494 | 5.83 |
PCP/CE pathway | R-HSA-4086400 | 6.47 |
Ca2+ pathway | R-HSA-4086398 | 7.1 |
Signal Transduction | R-HSA-162582 | 1.78 |
WNT5A-dependent internalization of FZD4 | R-HSA-5099900 | 9.08 |
TCF dependent signaling in response to WNT | R-HSA-201681 | 5.36 |
regulation of FZD by ubiquitination | R-HSA-4641263 | 8.59 |
GPCR ligand binding | R-HSA-500792 | 4.19 |
Signaling by WNT in cancer | R-HSA-4791275 | 7.89 |
Disease | R-HSA-1643685 | 3.33 |
GO term | GO ID | GO IC |
---|---|---|
G-protein coupled receptor activity | GO:0004930 | 2.95 |
ubiquitin protein ligase binding | GO:0031625 | 4.17 |
ubiquitin-like protein ligase binding | GO:0044389 | 4.15 |
protein binding | GO:0005515 | 0.46 |
protein heterodimerization activity | GO:0046982 | 3.64 |
identical protein binding | GO:0042802 | 2.63 |
cytokine binding | GO:0019955 | 5.21 |
enzyme binding | GO:0019899 | 2.27 |
Wnt-activated receptor activity | GO:0042813 | 6.65 |
molecular transducer activity | GO:0060089 | 2.32 |
transmembrane signaling receptor activity | GO:0004888 | 2.57 |
PDZ domain binding | GO:0030165 | 5.22 |
receptor activity | GO:0004872 | 2.32 |
signal transducer activity | GO:0004871 | 2.28 |
Wnt-protein binding | GO:0017147 | 6.3 |
signaling receptor activity | GO:0038023 | 2.49 |
protein dimerization activity | GO:0046983 | 2.72 |
protein homodimerization activity | GO:0042803 | 3.16 |
transmembrane receptor activity | GO:0099600 | 2.53 |
protein domain specific binding | GO:0019904 | 3.32 |
binding | GO:0005488 | 0.18 |