Disease ID | Disease name | Source of annotation with GHRL | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
601665 | OBESITY | OMIM | link to OMIM | 15 | PPARGC1B, AGRP, PPARG, MC4R, ADRB3, CARTPT, UCP3, SIM1, POMC, ENPP1, ADRB2, SDC3, NR0B2, UCP1, GHRL |
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KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
cAMP signaling pathway | hsa04024 | 5.05 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Signaling by GPCR | R-HSA-372790 | 2.68 |
GPCR downstream signaling | R-HSA-388396 | 3.07 |
Class A/1 (Rhodopsin-like receptors) | R-HSA-373076 | 4.69 |
Gastrin-CREB signalling pathway via PKC and MAPK | R-HSA-881907 | 4.26 |
Peptide hormone metabolism | R-HSA-2980736 | 6.61 |
G alpha (q) signalling events | R-HSA-416476 | 5.42 |
Peptide ligand-binding receptors | R-HSA-375276 | 5.41 |
Synthesis, secretion, and deacylation of Ghrelin | R-HSA-422085 | 8.89 |
GPCR ligand binding | R-HSA-500792 | 4.19 |
Metabolism of proteins | R-HSA-392499 | 3.41 |
Signal Transduction | R-HSA-162582 | 1.78 |
GO term | GO ID | GO IC |
---|---|---|
hormone activity | GO:0005179 | 4.95 |
kinase regulator activity | GO:0019207 | 4.5 |
protein kinase regulator activity | GO:0019887 | 4.6 |
enzyme regulator activity | GO:0030234 | 2.85 |
kinase activator activity | GO:0019209 | 5.58 |
growth hormone-releasing hormone activity | GO:0016608 | 9.05 |
ghrelin receptor binding | GO:0031768 | 9.74 |
binding | GO:0005488 | 0.18 |
protein binding | GO:0005515 | 0.46 |
G-protein coupled receptor binding | GO:0001664 | 4.18 |
receptor binding | GO:0005102 | 2.43 |
molecular function regulator | GO:0098772 | 2.51 |
protein kinase activator activity | GO:0030295 | 5.68 |
protein tyrosine kinase activator activity | GO:0030296 | 6.91 |
enzyme activator activity | GO:0008047 | 3.56 |