Gene table of GLI2 : GLI family zinc finger 2

Gene-disease associations table

Disease ID	Disease name	Source of annotation with GLI2	OMIM link	Number of associated genes	genes
PS236100	HOLOPROSENCEPHALY	ClinVar, OMIM, HUMSAVAR	link to OMIM	8	GAS1, PTCH1, GLI2, SIX3, SHH, TGIF1, CDON, ZIC2
615849	CULLER-JONES SYNDROME	OMIM, HUMSAVAR	link to OMIM	1	GLI2

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Annotation of the gene GLI2

Associated genes in ENSEMBL

ENSG00000074047

Associated proteins - SwissProt Accession ID

P10070

Associated PDB IDs

Cytogenetic Band

2q14.2

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Hedgehog signaling pathway	hsa04340	7.01
Hippo signaling pathway	hsa04390	5.37
Pathways in cancer	hsa05200	3.98
Basal cell carcinoma	hsa05217	6.79

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Degradation of GLI2 by the proteasome	R-HSA-5610783	7.1
Hedgehog 'off' state	R-HSA-5610787	6.19
GLI proteins bind promoters of Hh responsive genes to promote transcription	R-HSA-5635851	11.4
Hedgehog 'on' state	R-HSA-5632684	6.62
Signaling by Hedgehog	R-HSA-5358351	5.79
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
binding	GO:0005488	0.18
RNA polymerase II regulatory region DNA binding	GO:0001012	3.36
core promoter proximal region DNA binding	GO:0001159	3.82
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0001077	4.31
macromolecular complex binding	GO:0044877	2.61
zinc ion binding	GO:0008270	2.66
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
transition metal ion binding	GO:0046914	2.48
ion binding	GO:0043167	1.36
core promoter proximal region sequence-specific DNA binding	GO:0000987	3.83
double-stranded DNA binding	GO:0003690	3.09
metal ion binding	GO:0046872	1.41
transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding	GO:0000982	3.94
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
cation binding	GO:0043169	1.4
regulatory region nucleic acid binding	GO:0001067	3.03
transcription regulatory region DNA binding	GO:0044212	3.03
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
organic cyclic compound binding	GO:0097159	1.05
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
transcription regulatory region sequence-specific DNA binding	GO:0000976	3.24
RNA polymerase II regulatory region sequence-specific DNA binding	GO:0000977	3.37
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
RNA polymerase II core promoter proximal region sequence-specific DNA binding	GO:0000978	3.88
chromatin binding	GO:0003682	3.64
nucleic acid binding transcription factor activity	GO:0001071	2.65