Gene table of GNAO1 : G protein subunit alpha o1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with GNAO1	OMIM link	Number of associated genes	genes
PS308350	EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE	ClinVar, OMIM, HUMSAVAR	link to OMIM	37	KCNT1, EEF1A2, SZT2, ALG13, ST3GAL3, WWOX, ITPA, SIK1, SCN1A, ARHGEF9, GNAO1, TBC1D24, DNM1, SLC35A2, GRIN2B, SLC13A5, SLC25A22, HCN1, KCNB1, STXBP1, SCN9A, PNKP, KCNQ2, SPTAN1, KCNA2, SCN2A, PLCB1, AARS, PCDH19, CDKL5, GABRA1, SLC12A5, DOCK7, ARX, SCN8A, NECAP1, PIGA

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Annotation of the gene GNAO1

Associated genes in ENSEMBL

ENSG00000087258

Associated proteins - SwissProt Accession ID

P09471

Associated PDB IDs

Cytogenetic Band

16q13

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Morphine addiction	hsa05032	6.15
Alcoholism	hsa05034	5.59
Estrogen signaling pathway	hsa04915	6.11
Toxoplasmosis	hsa05145	5.71
Dopaminergic synapse	hsa04728	5.69
Retrograde endocannabinoid signaling	hsa04723	6.03
Chagas disease (American trypanosomiasis)	hsa05142	5.99
Rap1 signaling pathway	hsa04015	4.97
Cholinergic synapse	hsa04725	5.88
Oxytocin signaling pathway	hsa04921	5.4
GABAergic synapse	hsa04727	6.24
Serotonergic synapse	hsa04726	5.84
Melanogenesis	hsa04916	5.97
Circadian entrainment	hsa04713	6.11
Long-term depression	hsa04730	6.74
Glutamatergic synapse	hsa04724	5.84

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Signaling by Wnt	R-HSA-195721	4.79
PLC beta mediated events	R-HSA-112043	7.52
G-protein mediated events	R-HSA-112040	7.49
Opioid Signalling	R-HSA-111885	6.64
G-protein activation	R-HSA-202040	8.18
Ca2+ pathway	R-HSA-4086398	7.1
Signaling by GPCR	R-HSA-372790	2.68
beta-catenin independent WNT signaling	R-HSA-3858494	5.83
Signal Transduction	R-HSA-162582	1.78

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
GTPase activating protein binding	GO:0032794	7.1
corticotropin-releasing hormone receptor binding	GO:0051429	7.95
G-protein beta/gamma-subunit complex binding	GO:0031683	6.65
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
signal transducer activity	GO:0004871	2.28
G-protein coupled receptor binding	GO:0001664	4.18
ion binding	GO:0043167	1.36
corticotropin-releasing hormone receptor 1 binding	GO:0051430	8.35
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
cation binding	GO:0043169	1.4
pyrophosphatase activity	GO:0016462	3.04
heterocyclic compound binding	GO:1901363	1.06
guanyl ribonucleotide binding	GO:0032561	3.73
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
protein complex binding	GO:0032403	3.09
purine nucleotide binding	GO:0017076	2.19
metal ion binding	GO:0046872	1.41
GTP binding	GO:0005525	3.78
hydrolase activity	GO:0016787	1.9
mu-type opioid receptor binding	GO:0031852	8.35
nucleotide binding	GO:0000166	1.96
GTPase activity	GO:0003924	4.31
nucleoside-triphosphatase activity	GO:0017111	3.09
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
peptide hormone receptor binding	GO:0051428	6.91
G-protein coupled serotonin receptor binding	GO:0031821	7.79
neuropeptide receptor binding	GO:0071855	6.37
hormone receptor binding	GO:0051427	4.57
hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	GO:0016818	3.03
carbohydrate derivative binding	GO:0097367	2.03
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on acid anhydrides	GO:0016817	3.03
opioid receptor binding	GO:0031628	7.54
guanyl nucleotide binding	GO:0019001	3.73
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
receptor binding	GO:0005102	2.43
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19