Disease ID | Disease name | Source of annotation with GRIA3 | OMIM link | Number of associated genes | genes |
---|---|---|---|---|---|
PS309530 | MENTAL RETARDATION, NONSYNDROMIC, X-LINKED | ClinVar, OMIM, HUMSAVAR | link to OMIM | 25 | THOC2, HCFC1, RPS6KA3, USP9X, MID2, RAB39B, KIAA2022, ZNF81, PAK3, IQSEC2, DLG3, TSPAN7, ZDHHC15, ZNF711, KIF4A, ACSL4, BRWD3, IL1RAPL1, GDI1, SYP, ARHGEF6, ARX, DDX3X, GRIA3, FTSJ1 |
PS309510 | MENTAL RETARDATION, X-LINKED SYNDROMIC | ClinVar, OMIM, HUMSAVAR | link to OMIM | 27 | AP1S2, PRPS1, SMS, RBMX, HUWE1, RAB40AL, HSD17B10, ATP6AP2, FGD1, PHF8, CLIC2, CASK, TAF1, IGBP1, CUL4B, PQBP1, NONO, UPF3B, ZDHHC9, HDAC8, UBE2A, MECP2, KDM5C, ARX, SLC9A6, GRIA3, PHF6 |
Download the gene annotation in CSV format
KEGG pathway | KEGG ID | KEGG IC |
---|---|---|
cAMP signaling pathway | hsa04024 | 5.05 |
Transcriptional misregulation in cancer | hsa05202 | 5.21 |
Nicotine addiction | hsa05033 | 7.38 |
Retrograde endocannabinoid signaling | hsa04723 | 6.03 |
Amphetamine addiction | hsa05031 | 6.62 |
Glutamatergic synapse | hsa04724 | 5.84 |
Dopaminergic synapse | hsa04728 | 5.69 |
Circadian entrainment | hsa04713 | 6.11 |
Neuroactive ligand-receptor interaction | hsa04080 | 4.58 |
Long-term depression | hsa04730 | 6.74 |
REACTOME pathway | REACTOME ID | REACTOME IC |
---|---|---|
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity | R-HSA-399721 | 8.08 |
Trafficking of GluR2-containing AMPA receptors | R-HSA-416993 | 8.98 |
Trafficking of AMPA receptors | R-HSA-399719 | 8.08 |
Unblocking of NMDA receptor, glutamate binding and activation | R-HSA-438066 | 8.89 |
Activation of AMPA receptors | R-HSA-399710 | 10.98 |
Neuronal System | R-HSA-112316 | 4.82 |
Activation of NMDA receptor upon glutamate binding and postsynaptic events | R-HSA-442755 | 7.7 |
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | R-HSA-112314 | 5.85 |
Transmission across Chemical Synapses | R-HSA-112315 | 5.28 |
GO term | GO ID | GO IC |
---|---|---|
signaling receptor activity | GO:0038023 | 2.49 |
ligand-gated ion channel activity | GO:0015276 | 4.8 |
molecular transducer activity | GO:0060089 | 2.32 |
glutamate receptor activity | GO:0008066 | 6.44 |
receptor activity | GO:0004872 | 2.32 |
signal transducer activity | GO:0004871 | 2.28 |
ionotropic glutamate receptor activity | GO:0004970 | 6.79 |
AMPA glutamate receptor activity | GO:0004971 | 8.35 |
transmembrane signaling receptor activity | GO:0004888 | 2.57 |
transmitter-gated ion channel activity | GO:0022824 | 6.41 |
passive transmembrane transporter activity | GO:0022803 | 3.6 |
extracellular ligand-gated ion channel activity | GO:0005230 | 5.42 |
neurotransmitter receptor activity | GO:0030594 | 5.5 |
transporter activity | GO:0005215 | 2.57 |
ion channel activity | GO:0005216 | 3.71 |
excitatory extracellular ligand-gated ion channel activity | GO:0005231 | 5.73 |
extracellular-glutamate-gated ion channel activity | GO:0005234 | 6.74 |
substrate-specific transmembrane transporter activity | GO:0022891 | 2.9 |
substrate-specific transporter activity | GO:0022892 | 2.72 |
ion transmembrane transporter activity | GO:0015075 | 3.04 |
transmembrane transporter activity | GO:0022857 | 2.82 |
channel activity | GO:0015267 | 3.6 |
gated channel activity | GO:0022836 | 3.96 |
transmitter-gated channel activity | GO:0022835 | 6.41 |
ligand-gated channel activity | GO:0022834 | 4.8 |
substrate-specific channel activity | GO:0022838 | 3.67 |
transmembrane receptor activity | GO:0099600 | 2.53 |