Gene table of GUCY1A3 : guanylate cyclase 1 soluble subunit alpha

Gene-disease associations table

Disease ID	Disease name	Source of annotation with GUCY1A3	OMIM link	Number of associated genes	genes
PS252350	MOYAMOYA DISEASE	ClinVar, OMIM	link to OMIM	3	RNF213, GUCY1A3, ACTA2

Associated genes in ENSEMBL

Associated proteins - SwissProt Accession ID

Associated PDB IDs

Cytogenetic Band

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Salivary secretion	hsa04970	6.23
Platelet activation	hsa04611	5.66
Gap junction	hsa04540	6.24
cGMP-PKG signaling pathway	hsa04022	5.32
Oxytocin signaling pathway	hsa04921	5.4
Purine metabolism	hsa00230	5.28
Circadian entrainment	hsa04713	6.11
Long-term depression	hsa04730	6.74
Vascular smooth muscle contraction	hsa04270	5.74

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Platelet homeostasis	R-HSA-418346	6.68
Nitric oxide stimulates guanylate cyclase	R-HSA-392154	8.34
Hemostasis	R-HSA-109582	3.98

Associated GO terms for Molecular function

GO term	GO ID	GO IC
purine ribonucleoside triphosphate binding	GO:0035639	2.22
adenylate cyclase activity	GO:0004016	6.74
molecular transducer activity	GO:0060089	2.32
binding	GO:0005488	0.18
ion binding	GO:0043167	1.36
heterocyclic compound binding	GO:1901363	1.06
nucleoside phosphate binding	GO:1901265	1.96
nucleoside binding	GO:0001882	2.21
guanyl nucleotide binding	GO:0019001	3.73
lyase activity	GO:0016829	4.53
phosphorus-oxygen lyase activity	GO:0016849	6.6
nucleotide binding	GO:0000166	1.96
guanyl ribonucleotide binding	GO:0032561	3.73
purine nucleoside binding	GO:0001883	2.22
ribonucleoside binding	GO:0032549	2.22
purine nucleotide binding	GO:0017076	2.19
GTP binding	GO:0005525	3.78
heme binding	GO:0020037	4.86
guanylate cyclase activity	GO:0004383	7.54
small molecule binding	GO:0036094	1.89
catalytic activity	GO:0003824	1.05
tetrapyrrole binding	GO:0046906	4.8
cyclase activity	GO:0009975	6.6
organic cyclic compound binding	GO:0097159	1.05
carbohydrate derivative binding	GO:0097367	2.03
protein binding	GO:0005515	0.46
purine ribonucleotide binding	GO:0032555	2.2
protein dimerization activity	GO:0046983	2.72
protein heterodimerization activity	GO:0046982	3.64
purine ribonucleoside binding	GO:0032550	2.22
ribonucleotide binding	GO:0032553	2.19
receptor activity	GO:0004872	2.32