Gene table of HBA1 : hemoglobin subunit alpha 1

Gene-disease associations table

Disease IDDisease nameSource of annotation with HBA1OMIM linkNumber of associated genesgenes
613978HEMOGLOBIN H DISEASEOMIM link to OMIM 2HBA1, HBA2
604131ALPHA-THALASSEMIAOMIM link to OMIM 2HBA1, HBA2
140700HEINZ BODY ANEMIASOMIM link to OMIM 3HBA1, HBB, HBA2

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Annotation of the gene HBA1

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation

The gene is in the tandem Group 681, together with the genes:

Transcription regulation as annotated in TRRUST

It is regulated by the following TF:

Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
African trypanosomiasishsa051437.68
Malariahsa051447.15
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
Scavenging of heme from plasmaR-HSA-21688805.61
O2/CO2 exchange in erythrocytesR-HSA-14809269.98
Erythrocytes take up oxygen and release carbon dioxideR-HSA-12476739.98
MetabolismR-HSA-14307282.34
Binding and Uptake of Ligands by Scavenger ReceptorsR-HSA-21737825.38
Erythrocytes take up carbon dioxide and release oxygenR-HSA-12370449.98
Vesicle-mediated transportR-HSA-56536564.33
Associated GO terms for Molecular function
GO termGO IDGO IC
cation bindingGO:00431691.4
oxygen transporter activityGO:00053447.17
substrate-specific transporter activityGO:00228922.72
transition metal ion bindingGO:00469142.48
heme bindingGO:00200374.86
tetrapyrrole bindingGO:00469064.8
metal ion bindingGO:00468721.41
organic cyclic compound bindingGO:00971591.05
antioxidant activityGO:00162095.49
haptoglobin bindingGO:00317209.05
catalytic activityGO:00038241.05
heterocyclic compound bindingGO:19013631.06
ion bindingGO:00431671.36
oxygen bindingGO:00198255.89
bindingGO:00054880.18
protein bindingGO:00055150.46
transporter activityGO:00052152.57
iron ion bindingGO:00055064.65
oxidoreductase activity, acting on peroxide as acceptorGO:00166846.0
peroxidase activityGO:00046016.05
oxidoreductase activityGO:00164913.12