Gene table of HDAC6 : histone deacetylase 6

Gene-disease associations table

Disease ID	Disease name	Source of annotation with HDAC6	OMIM link	Number of associated genes	genes
300863	CHONDRODYSPLASIA WITH PLATYSPONDYLY, DISTINCTIVE BRACHYDACTYLY, HYDROCEPHALY, AND MICROPHTHALMIA	OMIM	link to OMIM	1	HDAC6

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Annotation of the gene HDAC6

Associated genes in ENSEMBL

ENSG00000094631

Associated proteins - SwissProt Accession ID

Q9UBN7

Associated PDB IDs

Cytogenetic Band

Xp11.23

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

Associated KEGG pathways

KEGG pathway	KEGG ID	KEGG IC
Viral carcinogenesis	hsa05203	5.08
Alcoholism	hsa05034	5.59

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
HSF1 activation	R-HSA-3371511	9.4
Signaling by NOTCH1	R-HSA-1980143	6.81
Diseases of signal transduction	R-HSA-5663202	4.89
Signaling by NOTCH1 in Cancer	R-HSA-2644603	7.15
Signaling by NOTCH1 PEST Domain Mutants in Cancer	R-HSA-2644602	7.15
Cellular responses to stress	R-HSA-2262752	4.56
Constitutive Signaling by NOTCH1 PEST Domain Mutants	R-HSA-2644606	7.15
Cellular response to heat stress	R-HSA-3371556	6.59
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer	R-HSA-2894858	7.15
NOTCH1 Intracellular Domain Regulates Transcription	R-HSA-2122947	7.43
Signal Transduction	R-HSA-162582	1.78
Assembly of the primary cilium	R-HSA-5617833	5.44
Signaling by NOTCH	R-HSA-157118	6.2
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants	R-HSA-2894862	7.15
Organelle biogenesis and maintenance	R-HSA-1852241	4.63
Disease	R-HSA-1643685	3.33

Associated GO terms for Molecular function

GO term	GO ID	GO IC
NAD-dependent histone deacetylase activity (H3-K14 specific)	GO:0032041	7.25
histone deacetylase activity (H3-K14 specific)	GO:0031078	7.25
ubiquitin-like protein ligase binding	GO:0044389	4.15
heat shock protein binding	GO:0031072	5.24
DNA binding	GO:0003677	1.92
deacetylase activity	GO:0019213	5.7
enzyme binding	GO:0019899	2.27
beta-tubulin binding	GO:0048487	6.13
Hsp90 protein binding	GO:0051879	6.37
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
polyubiquitin binding	GO:0031593	5.98
heterocyclic compound binding	GO:1901363	1.06
cation binding	GO:0043169	1.4
dynein complex binding	GO:0070840	8.64
transition metal ion binding	GO:0046914	2.48
histone deacetylase activity	GO:0004407	6.0
ion binding	GO:0043167	1.36
actin binding	GO:0003779	3.74
tubulin deacetylase activity	GO:0042903	9.05
protein complex binding	GO:0032403	3.09
metal ion binding	GO:0046872	1.41
histone deacetylase binding	GO:0042826	5.08
hydrolase activity	GO:0016787	1.9
tubulin binding	GO:0015631	4.1
NAD-dependent histone deacetylase activity	GO:0017136	6.97
microtubule binding	GO:0008017	4.42
regulatory region nucleic acid binding	GO:0001067	3.03
tau protein binding	GO:0048156	7.25
catalytic activity	GO:0003824	1.05
beta-catenin binding	GO:0008013	5.3
core promoter binding	GO:0001047	4.71
transcription regulatory region DNA binding	GO:0044212	3.03
ubiquitin protein ligase binding	GO:0031625	4.17
cytoskeletal protein binding	GO:0008092	3.02
organic cyclic compound binding	GO:0097159	1.05
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	GO:0016810	4.76
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	GO:0016811	5.28
ubiquitin-like protein binding	GO:0032182	4.93
NAD-dependent protein deacetylase activity	GO:0034979	6.85
ubiquitin binding	GO:0043130	5.09
misfolded protein binding	GO:0051787	7.25
protein binding	GO:0005515	0.46
regulatory region DNA binding	GO:0000975	3.03
alpha-tubulin binding	GO:0043014	6.37
protein deacetylase activity	GO:0033558	5.95
zinc ion binding	GO:0008270	2.66