Gene table of HMGA1 : high mobility group AT-hook 1

Gene-disease associations table

Disease ID	Disease name	Source of annotation with HMGA1	OMIM link	Number of associated genes	genes
125853	DIABETES MELLITUS, NONINSULIN-DEPENDENT	OMIM	link to OMIM	33	SLC2A2, HNF4A, TCF7L2, SLC30A8, GPD2, PAX4, PTPN1, SLC2A4, ABCC8, HMGA1, LIPC, NEUROD1, CDKAL1, WFS1, PPARG, RETN, AKT2, IRS2, IL6, IRS1, GCGR, CAPN10, IGF2BP2, INSR, PDX1, MTNR1B, GCK, HNF1B, HNF1A, MAPK8IP1, ENPP1, PPP1R3A, KCNJ11

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Annotation of the gene HMGA1

Associated genes in ENSEMBL

ENSG00000137309

Associated proteins - SwissProt Accession ID

P17096

Associated PDB IDs

Cytogenetic Band

6p21.31

Tandem repeats annotation

Transcription regulation as annotated in TRRUST

It is a TF of the genes:

It is regulated by the following TF:

Associated KEGG pathways

Associated REACTOME pathways

REACTOME pathway	REACTOME ID	REACTOME IC
Infectious disease	R-HSA-5663205	4.47
Formation of Senescence-Associated Heterochromatin Foci (SAHF)	R-HSA-2559584	8.98
Interactions of Vpr with host cellular proteins	R-HSA-176033	7.89
DNA Damage/Telomere Stress Induced Senescence	R-HSA-2559586	7.15
APOBEC3G mediated resistance to HIV-1 infection	R-HSA-180689	10.66
Cellular Senescence	R-HSA-2559583	5.7
Host Interactions of HIV factors	R-HSA-162909	5.99
Autointegration results in viral DNA circles	R-HSA-177539	11.4
Cellular responses to stress	R-HSA-2262752	4.56
HIV Infection	R-HSA-162906	5.22
Vpr-mediated nuclear import of PICs	R-HSA-180910	8.03
Integration of viral DNA into host genomic DNA	R-HSA-175567	11.4
2-LTR circle formation	R-HSA-164843	10.18
Early Phase of HIV Life Cycle	R-HSA-162594	9.4
Integration of provirus	R-HSA-162592	9.81
Disease	R-HSA-1643685	3.33
HIV Life Cycle	R-HSA-162587	5.89

Associated GO terms for Molecular function

GO term	GO ID	GO IC
enzyme binding	GO:0019899	2.27
transcription cofactor activity	GO:0003712	3.44
macromolecular complex binding	GO:0044877	2.61
binding	GO:0005488	0.18
nucleic acid binding	GO:0003676	1.44
DNA binding	GO:0003677	1.92
heterocyclic compound binding	GO:1901363	1.06
sequence-specific DNA binding	GO:0043565	2.79
sequence-specific double-stranded DNA binding	GO:1990837	3.2
lyase activity	GO:0016829	4.53
transcription coactivator activity	GO:0003713	4.04
endodeoxyribonuclease activity	GO:0004520	5.81
transcription factor activity, transcription factor binding	GO:0000989	3.36
transcription factor activity, protein binding	GO:0000988	3.35
double-stranded DNA binding	GO:0003690	3.09
deoxyribonuclease activity	GO:0004536	5.48
RNA polymerase II transcription factor activity, sequence-specific DNA binding	GO:0000981	3.29
hydrolase activity	GO:0016787	1.9
transcription factor binding	GO:0008134	3.46
nuclear hormone receptor binding	GO:0035257	4.7
hydrolase activity, acting on ester bonds	GO:0016788	3.1
ligand-dependent nuclear receptor transcription coactivator activity	GO:0030374	5.77
DNA-(apurinic or apyrimidinic site) lyase activity	GO:0003906	7.1
catalytic activity	GO:0003824	1.05
retinoid X receptor binding	GO:0046965	6.79
AT DNA binding	GO:0003680	7.66
hormone receptor binding	GO:0051427	4.57
transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0001205	6.48
5'-deoxyribose-5-phosphate lyase activity	GO:0051575	8.13
nuclease activity	GO:0004518	4.33
organic cyclic compound binding	GO:0097159	1.05
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding	GO:0003705	5.23
transcription factor activity, sequence-specific DNA binding	GO:0003700	2.65
endonuclease activity	GO:0004519	4.78
protein binding	GO:0005515	0.46
carbon-oxygen lyase activity	GO:0016835	5.46
retinoic acid receptor binding	GO:0042974	5.83
peroxisome proliferator activated receptor binding	GO:0042975	7.03
receptor binding	GO:0005102	2.43
chromatin binding	GO:0003682	3.64
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding	GO:0001228	3.98
nucleic acid binding transcription factor activity	GO:0001071	2.65