Gene table of IDH2 : isocitrate dehydrogenase (NADP(+)) 2, mitochondrial

Gene-disease associations table

Disease IDDisease nameSource of annotation with IDH2OMIM linkNumber of associated genesgenes
PS137800GLIOMAHUMSAVAR link to OMIM 8PTEN, PPARG, ERBB2, POT1, BRCA2, IDH2, IDH1, TP53
PS600721D-2-HYDROXYGLUTARIC ACIDURIAOMIM, HUMSAVAR link to OMIM 2IDH2, D2HGDH

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Annotation of the gene IDH2

Associated genes in ENSEMBL
Associated proteins - SwissProt Accession ID
Associated PDB IDs
Cytogenetic Band
Tandem repeats annotation
Transcription regulation as annotated in TRRUST
Associated KEGG pathways
KEGG pathwayKEGG IDKEGG IC
Metabolic pathwayshsa011002.49
Carbon metabolismhsa012006.03
Glutathione metabolismhsa004806.96
Citrate cycle (TCA cycle)hsa000207.86
Peroxisomehsa041466.34
Biosynthesis of amino acidshsa012306.58
2-Oxocarboxylic acid metabolismhsa012108.68
Associated REACTOME pathways
REACTOME pathwayREACTOME IDREACTOME IC
The citric acid (TCA) cycle and respiratory electron transportR-HSA-14285175.71
Pyruvate metabolism and Citric Acid (TCA) cycleR-HSA-714067.56
MetabolismR-HSA-14307282.34
Citric acid cycle (TCA cycle)R-HSA-714038.73
Associated GO terms for Molecular function
GO termGO IDGO IC
coenzyme bindingGO:00506624.53
metal ion bindingGO:00468721.41
oxidoreductase activity, acting on CH-OH group of donorsGO:00166144.83
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptorGO:00166165.0
catalytic activityGO:00038241.05
organic cyclic compound bindingGO:00971591.05
magnesium ion bindingGO:00002874.41
cation bindingGO:00431691.4
ion bindingGO:00431671.36
small molecule bindingGO:00360941.89
isocitrate dehydrogenase (NADP+) activityGO:00044509.05
cofactor bindingGO:00480374.16
bindingGO:00054880.18
NAD bindingGO:00512875.77
isocitrate dehydrogenase activityGO:00044488.13
nucleotide bindingGO:00001661.96
heterocyclic compound bindingGO:19013631.06
nucleoside phosphate bindingGO:19012651.96
oxidoreductase activityGO:00164913.12